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Article: IL-1B-511 polymorphism is associated with increased risk of certain subtypes of gastric cancer in chinese: A case-control study

TitleIL-1B-511 polymorphism is associated with increased risk of certain subtypes of gastric cancer in chinese: A case-control study
Authors
Issue Date2010
Citation
American Journal of Gastroenterology, 2010, v. 105, n. 3, p. 557-564 How to Cite?
AbstractObjectives: The association of interleukin-1B (IL-1B)-511 polymorphism with gastric cancer is still controversial, and the association of IL-1B-511 polymorphism with subtypes of gastric cancer is still largely unknown. We investigated whether the association between IL-1B-511 polymorphism and gastric cancer risk varies by clinically important tumor characteristics and the prognostic value of this polymorphism in a large population-based case-control study among Chinese.Methods: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 1,010 gastric cancer patients and 1,500 healthy controls were enrolled in this study. Polymorphism in IL-1B-511 was analyzed by PCR-restriction fragment length polymorphism on 501 gastric cancers and 500 healthy controls.Results: Compared with the CC genotype, carriers of IL-1B-511 TT genotype had an increased gastric cancer risk (odds ratio (OR)=1.97, 95% confidence interval (CI)=1.29-3.01, P=0.0016). TT genotype was significantly associated with intestinal type of gastric cancer (OR=3.16, 95% CI1.74-5.71, P=0.0001) but not with diffuse or mixed-type gastric cancer. The test for OR heterogeneity between the intestinal-type and non-intestinal-type gastric cancers was statistically significant (P0.02). In subgroup analyses, TT genotype was found to be associated with poorly differentiated gastric cancer (OR=3.31, 95% CI1.43-3.60, P<0.0001), but not with moderately or well-differentiated gastric cancer. IL-1B-511 genotypes were not associated with the prognosis of gastric cancer patients.Conclustions: IL-1B polymorphism influences certain subtypes of gastric cancer according to the clinical and pathological features. Understanding the etiologic heterogeneity of gastric cancer may result in improvements in controlling this disorder. © 2010 by the American College of Gastroenterology.
Persistent Identifierhttp://hdl.handle.net/10722/207035
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946

 

DC FieldValueLanguage
dc.contributor.authorYu, Jun-
dc.contributor.authorZeng, Zhirong-
dc.contributor.authorWang, Shiyan-
dc.contributor.authorTian, Linwei-
dc.contributor.authorWu, Jian-
dc.contributor.authorXue, Ling-
dc.contributor.authorLee, Chungwa-
dc.contributor.authorZhang, Mingdong-
dc.contributor.authorGoggins, William B.-
dc.contributor.authorChen, Minhu-
dc.contributor.authorHu, Pinjin-
dc.contributor.authorSung, Joseph-
dc.date.accessioned2014-12-09T04:31:17Z-
dc.date.available2014-12-09T04:31:17Z-
dc.date.issued2010-
dc.identifier.citationAmerican Journal of Gastroenterology, 2010, v. 105, n. 3, p. 557-564-
dc.identifier.issn0002-9270-
dc.identifier.urihttp://hdl.handle.net/10722/207035-
dc.description.abstractObjectives: The association of interleukin-1B (IL-1B)-511 polymorphism with gastric cancer is still controversial, and the association of IL-1B-511 polymorphism with subtypes of gastric cancer is still largely unknown. We investigated whether the association between IL-1B-511 polymorphism and gastric cancer risk varies by clinically important tumor characteristics and the prognostic value of this polymorphism in a large population-based case-control study among Chinese.Methods: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 1,010 gastric cancer patients and 1,500 healthy controls were enrolled in this study. Polymorphism in IL-1B-511 was analyzed by PCR-restriction fragment length polymorphism on 501 gastric cancers and 500 healthy controls.Results: Compared with the CC genotype, carriers of IL-1B-511 TT genotype had an increased gastric cancer risk (odds ratio (OR)=1.97, 95% confidence interval (CI)=1.29-3.01, P=0.0016). TT genotype was significantly associated with intestinal type of gastric cancer (OR=3.16, 95% CI1.74-5.71, P=0.0001) but not with diffuse or mixed-type gastric cancer. The test for OR heterogeneity between the intestinal-type and non-intestinal-type gastric cancers was statistically significant (P0.02). In subgroup analyses, TT genotype was found to be associated with poorly differentiated gastric cancer (OR=3.31, 95% CI1.43-3.60, P<0.0001), but not with moderately or well-differentiated gastric cancer. IL-1B-511 genotypes were not associated with the prognosis of gastric cancer patients.Conclustions: IL-1B polymorphism influences certain subtypes of gastric cancer according to the clinical and pathological features. Understanding the etiologic heterogeneity of gastric cancer may result in improvements in controlling this disorder. © 2010 by the American College of Gastroenterology.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Gastroenterology-
dc.titleIL-1B-511 polymorphism is associated with increased risk of certain subtypes of gastric cancer in chinese: A case-control study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajg.2009.644-
dc.identifier.pmid19904240-
dc.identifier.scopuseid_2-s2.0-77949268979-
dc.identifier.volume105-
dc.identifier.issue3-
dc.identifier.spage557-
dc.identifier.epage564-
dc.identifier.eissn1572-0241-

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