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Article: Polymorphisms in interleukin-6-6331 influences the susceptibility of a chinese population to gastric cancer

TitlePolymorphisms in interleukin-6-6331 influences the susceptibility of a chinese population to gastric cancer
Authors
KeywordsIL-6
Polymorphism
Survival
Gastric cancer
Issue Date2011
Citation
Cancer Investigation, 2011, v. 29, n. 8, p. 564-572 How to Cite?
AbstractWe investigated the association of Interleukin (IL)-6-6331 polymorphisms with susceptibility to gastric cancer in 375 patients with gastric cancer and 386 age-and gender-matched healthy controls. After adjustment for the potential confounding effects of gender and age, IL-6-6331TC genotype was associated with a decreased risk of gastric cancer compared with the CC genotype. Further stratification analyses indicated that the protective effect of TC genotype was also observed in poorly differentiated gastric cancer, noncardia gastric cancer, and intestinal-type gastric cancer, respectively. These results suggest that the IL-6-6331 polymorphism is involved in susceptibility to developing gastric cancer. © 2011 Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/207028
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991

 

DC FieldValueLanguage
dc.contributor.authorYu, Jun-
dc.contributor.authorJia, Yanhong-
dc.contributor.authorCheung, Kinfai-
dc.contributor.authorZeng, Zhirong-
dc.contributor.authorTian, Linwei-
dc.contributor.authorWang, Shiyan-
dc.contributor.authorHu, Pinjin-
dc.contributor.authorSung, Joseph-
dc.date.accessioned2014-12-09T04:31:16Z-
dc.date.available2014-12-09T04:31:16Z-
dc.date.issued2011-
dc.identifier.citationCancer Investigation, 2011, v. 29, n. 8, p. 564-572-
dc.identifier.issn0735-7907-
dc.identifier.urihttp://hdl.handle.net/10722/207028-
dc.description.abstractWe investigated the association of Interleukin (IL)-6-6331 polymorphisms with susceptibility to gastric cancer in 375 patients with gastric cancer and 386 age-and gender-matched healthy controls. After adjustment for the potential confounding effects of gender and age, IL-6-6331TC genotype was associated with a decreased risk of gastric cancer compared with the CC genotype. Further stratification analyses indicated that the protective effect of TC genotype was also observed in poorly differentiated gastric cancer, noncardia gastric cancer, and intestinal-type gastric cancer, respectively. These results suggest that the IL-6-6331 polymorphism is involved in susceptibility to developing gastric cancer. © 2011 Informa Healthcare USA, Inc.-
dc.languageeng-
dc.relation.ispartofCancer Investigation-
dc.subjectIL-6-
dc.subjectPolymorphism-
dc.subjectSurvival-
dc.subjectGastric cancer-
dc.titlePolymorphisms in interleukin-6-6331 influences the susceptibility of a chinese population to gastric cancer-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/07357907.2011.605411-
dc.identifier.pmid21843047-
dc.identifier.scopuseid_2-s2.0-80052776259-
dc.identifier.volume29-
dc.identifier.issue8-
dc.identifier.spage564-
dc.identifier.epage572-
dc.identifier.eissn1532-4192-

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