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Article: Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances

TitleRegulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances
Authors
KeywordsBlood-testis barrier
Adherens junction
Tight junction
Hemidesmosome
Ectoplasmic specialization
Cytokines
Collagen chains
Basement membrane
Testis
Spermatogenesis
Seminiferous epithelial cycle
Laminin chains
Issue Date2010
Citation
Molecular and Cellular Endocrinology, 2010, v. 315, n. 1-2, p. 49-56 How to Cite?
AbstractSpermatogenesis is a complex biochemical event, involving the participation of the hypothalamus and the pituitary gland via secretion of the hypothalamus hormone GnRH, and two pituitary hormones FSH and LH. Thus, the hypothalamic-pituitary-testicular axis is a crucial regulatory axis for testicular function. Recent studies have shown that in the microenvironment of the seminiferous epithelium, wherein each Sertoli cell supports ∼30-50 germ cells at different stages of development, locally produced autocrine and paracrine factors are also involved in spermatogenesis, in particular at the level of cell junctions. These cell junctions at the Sertoli-Sertoli and Sertoli-germ cell interface are crucial for coordinating different events of spermatogenesis by sending signals back-and-forth between Sertoli and germ cells, in order to precisely regulate spermatogonial cell renewal by mitosis, cell cycle progression, meiosis, spermiogenesis, germ cell movement across the epithelium, spermiation and germ cell apoptosis. In this minireview, we provide an update on these latest findings for an emerging new concept regarding the presence of a local "apical ectoplasmic specialization-blood-testis barrier-hemidesmosome/basement membrane" functional axis that regulates the events of spermiation and blood-testis barrier (BTB) restructuring via paracrine/autocrine factors and polarity proteins produced locally in the seminiferous epithelium. These findings provide a new window of research for investigators in the field to tackle the functional regulation of spermatogenesis. © 2009 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/207019
ISSN
2015 Impact Factor: 3.859
2015 SCImago Journal Rankings: 2.116

 

DC FieldValueLanguage
dc.contributor.authorCheng, C. Yan-
dc.contributor.authorWong, Elissa W P-
dc.contributor.authorYan, Helen H N-
dc.contributor.authorMruk, Dolores D.-
dc.date.accessioned2014-12-09T04:31:15Z-
dc.date.available2014-12-09T04:31:15Z-
dc.date.issued2010-
dc.identifier.citationMolecular and Cellular Endocrinology, 2010, v. 315, n. 1-2, p. 49-56-
dc.identifier.issn0303-7207-
dc.identifier.urihttp://hdl.handle.net/10722/207019-
dc.description.abstractSpermatogenesis is a complex biochemical event, involving the participation of the hypothalamus and the pituitary gland via secretion of the hypothalamus hormone GnRH, and two pituitary hormones FSH and LH. Thus, the hypothalamic-pituitary-testicular axis is a crucial regulatory axis for testicular function. Recent studies have shown that in the microenvironment of the seminiferous epithelium, wherein each Sertoli cell supports ∼30-50 germ cells at different stages of development, locally produced autocrine and paracrine factors are also involved in spermatogenesis, in particular at the level of cell junctions. These cell junctions at the Sertoli-Sertoli and Sertoli-germ cell interface are crucial for coordinating different events of spermatogenesis by sending signals back-and-forth between Sertoli and germ cells, in order to precisely regulate spermatogonial cell renewal by mitosis, cell cycle progression, meiosis, spermiogenesis, germ cell movement across the epithelium, spermiation and germ cell apoptosis. In this minireview, we provide an update on these latest findings for an emerging new concept regarding the presence of a local "apical ectoplasmic specialization-blood-testis barrier-hemidesmosome/basement membrane" functional axis that regulates the events of spermiation and blood-testis barrier (BTB) restructuring via paracrine/autocrine factors and polarity proteins produced locally in the seminiferous epithelium. These findings provide a new window of research for investigators in the field to tackle the functional regulation of spermatogenesis. © 2009 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofMolecular and Cellular Endocrinology-
dc.subjectBlood-testis barrier-
dc.subjectAdherens junction-
dc.subjectTight junction-
dc.subjectHemidesmosome-
dc.subjectEctoplasmic specialization-
dc.subjectCytokines-
dc.subjectCollagen chains-
dc.subjectBasement membrane-
dc.subjectTestis-
dc.subjectSpermatogenesis-
dc.subjectSeminiferous epithelial cycle-
dc.subjectLaminin chains-
dc.titleRegulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.mce.2009.08.004-
dc.identifier.pmid19682538-
dc.identifier.scopuseid_2-s2.0-71849115693-
dc.identifier.hkuros175324-
dc.identifier.volume315-
dc.identifier.issue1-2-
dc.identifier.spage49-
dc.identifier.epage56-

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