File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: A case-control study in Xuan Wei, China

TitleIndoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: A case-control study in Xuan Wei, China
Authors
Issue Date2000
Citation
Cancer Epidemiology Biomarkers and Prevention, 2000, v. 9, n. 6, p. 605-608 How to Cite?
AbstractThe lung cancer mortality rate in Xuan Wei County, China is among the highest in the country and has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons. This risk may be modified by variation in metabolism genes, including GSTM1, which encodes an enzyme known to detoxify polycyclic aromatic hydrocarbons. To investigate the relationship between GST genotypes and lung cancer risk in Xuan Wei County, we analyzed GSTM1 and GSTT1 genotypes in a population-based case-control study. A total of 122 lung cancer patients and 122 controls, individually matched by age, sex, and home fuel type, were studied. Compared to subjects who used less than 130 tons of smoky coal during their lifetime, heavier users (≥130 tons) had a 2.4-fold (95% confidence interval, 1.3-4.4) increased risk of lung cancer. The GSTM1-null genotype was associated with a 2.3-fold (95% confidence interval, 1.3-4.2) increased risk of lung cancer. Furthermore, there was some evidence that smoky coal use was more strongly associated with lung cancer risk among GSTM1-null versus GSTM1-positive individuals. In contrast, the GSTT1 genotype was not significantly associated with lung cancer risk. Our data suggest that the GSTM1-null genotype may enhance susceptibility to air pollution from indoor coal combustion emissions.
Persistent Identifierhttp://hdl.handle.net/10722/206997
ISSN
2015 Impact Factor: 3.622
2015 SCImago Journal Rankings: 2.579

 

DC FieldValueLanguage
dc.contributor.authorLan, Qing-
dc.contributor.authorHe, Xingzhou-
dc.contributor.authorCosta, Debra J.-
dc.contributor.authorTian, Linwei-
dc.contributor.authorRothman, Nathaniel R.-
dc.contributor.authorHu, Guizhou-
dc.contributor.authorMumford, Judy Lee-
dc.date.accessioned2014-12-09T04:31:13Z-
dc.date.available2014-12-09T04:31:13Z-
dc.date.issued2000-
dc.identifier.citationCancer Epidemiology Biomarkers and Prevention, 2000, v. 9, n. 6, p. 605-608-
dc.identifier.issn1055-9965-
dc.identifier.urihttp://hdl.handle.net/10722/206997-
dc.description.abstractThe lung cancer mortality rate in Xuan Wei County, China is among the highest in the country and has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons. This risk may be modified by variation in metabolism genes, including GSTM1, which encodes an enzyme known to detoxify polycyclic aromatic hydrocarbons. To investigate the relationship between GST genotypes and lung cancer risk in Xuan Wei County, we analyzed GSTM1 and GSTT1 genotypes in a population-based case-control study. A total of 122 lung cancer patients and 122 controls, individually matched by age, sex, and home fuel type, were studied. Compared to subjects who used less than 130 tons of smoky coal during their lifetime, heavier users (≥130 tons) had a 2.4-fold (95% confidence interval, 1.3-4.4) increased risk of lung cancer. The GSTM1-null genotype was associated with a 2.3-fold (95% confidence interval, 1.3-4.2) increased risk of lung cancer. Furthermore, there was some evidence that smoky coal use was more strongly associated with lung cancer risk among GSTM1-null versus GSTM1-positive individuals. In contrast, the GSTT1 genotype was not significantly associated with lung cancer risk. Our data suggest that the GSTM1-null genotype may enhance susceptibility to air pollution from indoor coal combustion emissions.-
dc.languageeng-
dc.relation.ispartofCancer Epidemiology Biomarkers and Prevention-
dc.titleIndoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: A case-control study in Xuan Wei, China-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10868696-
dc.identifier.scopuseid_2-s2.0-0034130337-
dc.identifier.volume9-
dc.identifier.issue6-
dc.identifier.spage605-
dc.identifier.epage608-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats