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Patent History
- ApplicationUS 12/3871716 2013-04-26
- GrantedUS 20130295054 2013-11-07
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granted patent: Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor
Title | Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor |
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Granted Patent | US 20130295054 |
Granted Date | 2013-11-07 |
Priority Date | 2013-04-26 US 12/3871716 2012-05-04 US 12/1687975P |
Inventors | |
Issue Date | 2013 |
Citation | US Patent US 20130295054. Washington, DC: US Patent and Trademark Office (USPTO), 2013 How to Cite? |
Abstract | Described herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma. |
Persistent Identifier | http://hdl.handle.net/10722/206619 |
DC Field | Value | Language |
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dc.date.accessioned | 2014-11-21T08:05:29Z | - |
dc.date.available | 2014-11-21T08:05:29Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | US Patent US 20130295054. Washington, DC: US Patent and Trademark Office (USPTO), 2013 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/206619 | - |
dc.description.abstract | Described herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma. | en_US |
dc.title | Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor | en_US |
dc.type | Patent | en_US |
dc.identifier.authority | HUANG, JIAN-DONG=rp00451 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | HUANG, JIAN-DONG | en_US |
dc.contributor.inventor | YU, BIN | en_US |
dc.contributor.inventor | YANG, MEI | en_US |
dc.contributor.inventor | SHI, LEI | en_US |
patents.identifier.application | US 12/3871716 | en_US |
patents.identifier.granted | US 20130295054 | en_US |
patents.description.assignee | UNIV HONG KONG [CN] | en_US |
patents.description.country | United States of America | en_US |
patents.date.granted | 2013-11-07 | en_US |
patents.identifier.hkutechid | Bioch-2012-00422-1 | en_US |
patents.date.application | 2013-04-26 | en_US |
patents.date.priority | 2013-04-26 US 12/3871716 | en_US |
patents.date.priority | 2012-05-04 US 12/1687975P | en_US |
patents.description.cc | us | en_US |
patents.relation.family | WO 2013163893 (A1) 2013-11-07 | en_US |
patents.description.kind | A1 | en_US |
patents.type | Patent_granted | en_US |