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  Patent History
  • Application
    US 12/3871716 2013-04-26
  • Granted
    US 20130295054 2013-11-07
  Patent Family
Supplementary

granted patent: Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor

TitleModified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor
Granted PatentUS 20130295054
Granted Date2013-11-07
Priority Date2013-04-26 US 12/3871716
2012-05-04 US 12/1687975P
Inventors
Issue Date2013
Citation
US Patent US 20130295054. Washington, DC: US Patent and Trademark Office (USPTO), 2013 How to Cite?
AbstractDescribed herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma.
Persistent Identifierhttp://hdl.handle.net/10722/206619

 

DC FieldValueLanguage
dc.date.accessioned2014-11-21T08:05:29Z-
dc.date.available2014-11-21T08:05:29Z-
dc.date.issued2013en_US
dc.identifier.citationUS Patent US 20130295054. Washington, DC: US Patent and Trademark Office (USPTO), 2013en_US
dc.identifier.urihttp://hdl.handle.net/10722/206619-
dc.description.abstractDescribed herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleModified Bacteria and their Uses thereof for the Treatment of Cancer or Tumoren_US
dc.typePatenten_US
dc.identifier.authorityHUANG, JIAN-DONG=rp00451en_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorHUANG, JIAN-DONGen_US
dc.contributor.inventorYU, BINen_US
dc.contributor.inventorYANG, MEIen_US
dc.contributor.inventorSHI, LEIen_US
patents.identifier.applicationUS 12/3871716en_US
patents.identifier.grantedUS 20130295054en_US
patents.description.assigneeUNIV HONG KONG [CN]en_US
patents.description.countryUnited States of Americaen_US
patents.date.granted2013-11-07en_US
patents.identifier.hkutechidBioch-2012-00422-1en_US
patents.date.application2013-04-26en_US
patents.date.priority2013-04-26 US 12/3871716en_US
patents.date.priority2012-05-04 US 12/1687975Pen_US
patents.description.ccusen_US
patents.relation.familyWO 2013163893 (A1) 2013-11-07en_US
patents.description.kindA1en_US
patents.typePatent_granteden_US

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