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Article: Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

TitleImmunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure
Authors
Issue Date2013
Citation
Scientific Reports, 2013, v. 3, p. 1698 How to Cite?
AbstractEvolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/206175

 

DC FieldValueLanguage
dc.contributor.authorHuang, SSen_US
dc.contributor.authorLin, Zen_US
dc.contributor.authorBanner, Den_US
dc.contributor.authorLeón, AJen_US
dc.contributor.authorPaquette, SGen_US
dc.contributor.authorRubin, Ben_US
dc.contributor.authorRubino, Sen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorKelvin, DJen_US
dc.contributor.authorKelvin, AAen_US
dc.date.accessioned2014-10-20T13:39:04Z-
dc.date.available2014-10-20T13:39:04Z-
dc.date.issued2013en_US
dc.identifier.citationScientific Reports, 2013, v. 3, p. 1698en_US
dc.identifier.urihttp://hdl.handle.net/10722/206175-
dc.description.abstractEvolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.en_US
dc.languageengen_US
dc.relation.ispartofScientific Reportsen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleImmunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failureen_US
dc.typeArticleen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep01698en_US
dc.identifier.hkuros240936en_US
dc.identifier.volume3en_US
dc.identifier.spage1698en_US
dc.identifier.epage1698en_US

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