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Conference Paper: Drug utilization pattern in children with Autism Spectrum Disorder (ASD) in Asian countries: a population based study

TitleDrug utilization pattern in children with Autism Spectrum Disorder (ASD) in Asian countries: a population based study
Authors
KeywordsPharmacy and pharmacology
Issue Date2014
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669
Citation
The 30th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Taipei, Taiwan, 24-27 October 2014. In Pharmacoepidemiology and Drug Safety, 2014, v. 23 S1, p. 201, abstract no. 381 How to Cite?
AbstractBACKGROUND: A recent study has reported an increase rate of ASD in Chinese population. No current evidence on medication use for ASD treatment in Chinese children has been reported. There is need to investigate medication use in this population. OBJECTIVES: The aim of this study was to investigate the current pharmacological treatments patterns among a cohort of children diagnosed with ASD in Taiwan (TW) and Hong Kong (HK). METHODS: Patients who aged younger than 12 years old with autism diagnosis (ICD-9-CM 299.xx) were identified from the National Health Insurance Research Database (NHIRD) and registry for catastrophic illness between 2000 to 2010 in TW and the Clinical Data and Reporting System (CDARS) database between 2001 and 2010 in HK. Based on literature review, agents found to be possibly efficacious of those patients were studied. Psychotropic drug use was assessed within one year after the first diagnosis of ASD was recorded. Results: A total of 11,825 (5,501 from TW; 6,324 from HK) of ASD children were identified. The majority of patients were boys (84.0% for TW; 87.2% for HK), and median age at diagnosis were 5 years old in both areas. 2,354 patients (1,740 (31.6%) from TW, 614 (9.7%) from HK) received at least one prescription of psychotropic drug within the study period. There is variation of prescribing pattern in TW and HK. In TW, the most commonly prescribed medications were stimulants (1,018 patients, 58.5%), antipsychotics (615 patients, 35.3%), anxiolytics (477 patients, 27.4%), antidepressant (227 patients, 13.0%), and clonidine (128 patients, 7.4%). In HK, stimulants was also the most commonly prescribed medication (506 patients, 82.4%), followed by antipsychotics (133 patients, 21.7%), anxiolytics (78 patients, 12.7%), and antidepressant (31 patients, 5.0%). Of these stimulants, methylphenidate was the most commonly prescribed drug in both TW and HK (70.1% in TW, 92.1% in HK). CONCLUSIONS: This study showed one-third of ASD children received medication treatment in TW whereas it was only one-tenth of children received treatment in HK. Further research is needed to evaluate the effectiveness and safety of this utilization.
DescriptionThis journal suppl. entitled: Special Issue: Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ... 2014
Persistent Identifierhttp://hdl.handle.net/10722/206060
ISSN
2015 Impact Factor: 2.908
2015 SCImago Journal Rankings: 1.804

 

DC FieldValueLanguage
dc.contributor.authorCheng, CLen_US
dc.contributor.authorMan, KKCen_US
dc.contributor.authorHsia, YFen_US
dc.contributor.authorKao Yang, YHen_US
dc.contributor.authorWong, ICKen_US
dc.date.accessioned2014-10-20T11:58:42Z-
dc.date.available2014-10-20T11:58:42Z-
dc.date.issued2014en_US
dc.identifier.citationThe 30th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Taipei, Taiwan, 24-27 October 2014. In Pharmacoepidemiology and Drug Safety, 2014, v. 23 S1, p. 201, abstract no. 381en_US
dc.identifier.issn1053-8569-
dc.identifier.urihttp://hdl.handle.net/10722/206060-
dc.descriptionThis journal suppl. entitled: Special Issue: Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ... 2014-
dc.description.abstractBACKGROUND: A recent study has reported an increase rate of ASD in Chinese population. No current evidence on medication use for ASD treatment in Chinese children has been reported. There is need to investigate medication use in this population. OBJECTIVES: The aim of this study was to investigate the current pharmacological treatments patterns among a cohort of children diagnosed with ASD in Taiwan (TW) and Hong Kong (HK). METHODS: Patients who aged younger than 12 years old with autism diagnosis (ICD-9-CM 299.xx) were identified from the National Health Insurance Research Database (NHIRD) and registry for catastrophic illness between 2000 to 2010 in TW and the Clinical Data and Reporting System (CDARS) database between 2001 and 2010 in HK. Based on literature review, agents found to be possibly efficacious of those patients were studied. Psychotropic drug use was assessed within one year after the first diagnosis of ASD was recorded. Results: A total of 11,825 (5,501 from TW; 6,324 from HK) of ASD children were identified. The majority of patients were boys (84.0% for TW; 87.2% for HK), and median age at diagnosis were 5 years old in both areas. 2,354 patients (1,740 (31.6%) from TW, 614 (9.7%) from HK) received at least one prescription of psychotropic drug within the study period. There is variation of prescribing pattern in TW and HK. In TW, the most commonly prescribed medications were stimulants (1,018 patients, 58.5%), antipsychotics (615 patients, 35.3%), anxiolytics (477 patients, 27.4%), antidepressant (227 patients, 13.0%), and clonidine (128 patients, 7.4%). In HK, stimulants was also the most commonly prescribed medication (506 patients, 82.4%), followed by antipsychotics (133 patients, 21.7%), anxiolytics (78 patients, 12.7%), and antidepressant (31 patients, 5.0%). Of these stimulants, methylphenidate was the most commonly prescribed drug in both TW and HK (70.1% in TW, 92.1% in HK). CONCLUSIONS: This study showed one-third of ASD children received medication treatment in TW whereas it was only one-tenth of children received treatment in HK. Further research is needed to evaluate the effectiveness and safety of this utilization.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669-
dc.relation.ispartofPharmacoepidemiology and Drug Safetyen_US
dc.rightsPharmacoepidemiology and Drug Safety. Copyright © John Wiley & Sons Ltd.-
dc.subjectPharmacy and pharmacology-
dc.titleDrug utilization pattern in children with Autism Spectrum Disorder (ASD) in Asian countries: a population based studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailMan, KKC: mkckth@hku.hken_US
dc.identifier.emailWong, ICK: wongick@hku.hken_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.identifier.doi10.1002/pds.3701en_US
dc.identifier.hkuros241302en_US
dc.identifier.volume23-
dc.identifier.issueS1-
dc.identifier.spage201, abstract no. 381-
dc.identifier.epage201, abstract no. 381-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablesml 141110-

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