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Conference Paper: The role of oncogene in mycobacteria-induced antophagy in human macrophages
Title | The role of oncogene in mycobacteria-induced antophagy in human macrophages |
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Authors | |
Issue Date | 2014 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | The 2014 Joint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 15 June 2014. In the Hong Kong Journal of Paediatrics (New series), 2014, v. 19 n. 3, p. 202 How to Cite? |
Abstract | Macrophages are the major immunocytes to initiate
both innate and adaptive immune responses against
Mycobacterium tuberculosis (Mtb), a causative agent of
tuberculosis. Upon mycoabcteria infection, macrophages
could eliminate the intracellular bacteria through different
cell death pathways, including apoptosis and autophagy.
c-Myc is a transcription factor that regulates a variety
of target genes and control different cellular functions such
as proliferation and immune resposnse. Recently, our group
revealed that c-Myc has a potential role in regulating the
antimicrobial responses in macrophages.
Here we use BCG, a live attenuated strain of
Mycobacterium bovis, which is similar to Mtb in antigenic
composition, as a model to study the role of c-Myc in
regulating mycobacteria-induced autophagy. We first
investigated the role of c-Myc in BCG-induced LC3BII
levels. Knocking down c-Myc by siRNA could decrease
BCG-induced LC3BII levels. We found that BCG-induced
autophagy is dependent on JNK and p38 and independent
on PI3K or ERK pathways. And knocking down of c-Myc
could significantly inhibit phosphorylation of p38.
In conclusion, c-Myc may play a positive role in
mycobacteria-induced autophagy in human macrophages. |
Description | Poster Presentation |
Persistent Identifier | http://hdl.handle.net/10722/206052 |
ISSN | 2021 Impact Factor: 0.104 2020 SCImago Journal Rankings: 0.115 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, L | en_US |
dc.contributor.author | Ling, WL | en_US |
dc.contributor.author | Lau, ASY | en_US |
dc.contributor.author | Li, CB | en_US |
dc.date.accessioned | 2014-10-20T11:47:24Z | - |
dc.date.available | 2014-10-20T11:47:24Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 2014 Joint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 15 June 2014. In the Hong Kong Journal of Paediatrics (New series), 2014, v. 19 n. 3, p. 202 | en_US |
dc.identifier.issn | 1013-9923 | - |
dc.identifier.uri | http://hdl.handle.net/10722/206052 | - |
dc.description | Poster Presentation | - |
dc.description.abstract | Macrophages are the major immunocytes to initiate both innate and adaptive immune responses against Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis. Upon mycoabcteria infection, macrophages could eliminate the intracellular bacteria through different cell death pathways, including apoptosis and autophagy. c-Myc is a transcription factor that regulates a variety of target genes and control different cellular functions such as proliferation and immune resposnse. Recently, our group revealed that c-Myc has a potential role in regulating the antimicrobial responses in macrophages. Here we use BCG, a live attenuated strain of Mycobacterium bovis, which is similar to Mtb in antigenic composition, as a model to study the role of c-Myc in regulating mycobacteria-induced autophagy. We first investigated the role of c-Myc in BCG-induced LC3BII levels. Knocking down c-Myc by siRNA could decrease BCG-induced LC3BII levels. We found that BCG-induced autophagy is dependent on JNK and p38 and independent on PI3K or ERK pathways. And knocking down of c-Myc could significantly inhibit phosphorylation of p38. In conclusion, c-Myc may play a positive role in mycobacteria-induced autophagy in human macrophages. | - |
dc.language | eng | en_US |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | - |
dc.relation.ispartof | Hong Kong Journal of Paediatrics (New series) | en_US |
dc.title | The role of oncogene in mycobacteria-induced antophagy in human macrophages | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wang, L: vickyw@hku.hk | en_US |
dc.identifier.email | Ling, WL: lingwl@graduate.hku.hk | en_US |
dc.identifier.email | Lau, ASY: asylau@hku.hk | en_US |
dc.identifier.email | Li, CB: jamesli@graduate.hku.hk | en_US |
dc.identifier.authority | Lau, ASY=rp00474 | en_US |
dc.identifier.authority | Li, CB=rp00496 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 241332 | en_US |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 202 | - |
dc.identifier.epage | 202 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1013-9923 | - |