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Conference Paper: A Role of Interleukin-17A in Modulating Intracellular Survival of Mycobacterium Bovis BCG in Murine Macrophages

TitleA Role of Interleukin-17A in Modulating Intracellular Survival of Mycobacterium Bovis BCG in Murine Macrophages
Authors
Issue Date2013
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Joint Annual Scientific Meeting 2013 of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, , v. 18 n. 4, p. 250 How to Cite?
AbstractInterleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able Interleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able
DescriptionPoster Presentation (Doctor’s Session)
Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf
Persistent Identifierhttp://hdl.handle.net/10722/206042
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorLing, WLen_US
dc.contributor.authorWang, Len_US
dc.contributor.authorPong, CHen_US
dc.contributor.authorLau, ASYen_US
dc.contributor.authorLi, CBen_US
dc.date.accessioned2014-10-20T11:47:22Z-
dc.date.available2014-10-20T11:47:22Z-
dc.date.issued2013en_US
dc.identifier.citationJoint Annual Scientific Meeting 2013 of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, , v. 18 n. 4, p. 250en_US
dc.identifier.issn1013-9923-
dc.identifier.urihttp://hdl.handle.net/10722/206042-
dc.descriptionPoster Presentation (Doctor’s Session)-
dc.descriptionFulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf-
dc.description.abstractInterleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able Interleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able-
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp-
dc.relation.ispartofHong Kong Journal of Paediatrics (New series)en_US
dc.titleA Role of Interleukin-17A in Modulating Intracellular Survival of Mycobacterium Bovis BCG in Murine Macrophagesen_US
dc.typeConference_Paperen_US
dc.identifier.emailLing, WL: lingwl@graduate.hku.hken_US
dc.identifier.emailWang, L: vickyw@hku.hken_US
dc.identifier.emailPong, CH: jchpong@hku.hken_US
dc.identifier.emailLau, ASY: asylau@hku.hken_US
dc.identifier.emailLi, CB: jamesli@graduate.hku.hken_US
dc.identifier.authorityLau, ASY=rp00474en_US
dc.identifier.authorityLi, CB=rp00496en_US
dc.identifier.hkuros241315en_US
dc.identifier.volume18-
dc.identifier.issue4-
dc.identifier.spage250-
dc.identifier.epage250-
dc.publisher.placeHong Kong-

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