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Conference Paper: Regulation of HIV-Tat Induced Cytokine Expression and Consequent Opportunistic Infection by The Proto-Oncogene c-Myc

TitleRegulation of HIV-Tat Induced Cytokine Expression and Consequent Opportunistic Infection by The Proto-Oncogene c-Myc
Authors
Issue Date2013
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Joint Annual Scientific Meeting 2013 of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 234 How to Cite?
AbstractHuman immunodeficiency virus (HIV) remains a major health problem around the globe, especially in third world countries where acquired immunodeficiency syndrome (AIDS) is highly prevalent and currently incurable. The HIV-1 trans-activator (Tat) protein is an important viral protein that is known to contribute to the AIDS pathogenesis via the dysregulation of cytokines such as TNF-α and IL- 6. In this study, we recognised that c-Myc, a proto-oncogene known to regulate a wide range of cellular process, also regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. We first found that HIV-1 Tat could induce the expression of c-Myc.The function and expression of HIV- 1 Tat induced c-Myc was subsequently found to be regulated through the activation of the dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). Inhibition of c-Myc expression in turn demonstrated that c-Myc may be essential for the up-regulation of the pro-inflammatory cytokines TNF-α and IL-6 by HIV-1 Tat. Furthermore, c-Myc regulation of HIV-1 Tat induced cytokine expression consequently affected the intracellular survival of the opportunistic microbe, Mycobacteria avium intracellulare, in PBMac. Taken together, we demonstrated that c-Myc may play a significant role in the pathogenesis of AIDS, by mediating the dysregulation of cytokine expression induced by Tat and possibly accentuate opportunistic infection.
DescriptionOral Presentation (Doctor’s Session)
Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf
Persistent Identifierhttp://hdl.handle.net/10722/206041
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorPong, CHen_US
dc.contributor.authorLi, CBen_US
dc.contributor.authorLau, ASYen_US
dc.date.accessioned2014-10-20T11:47:20Z-
dc.date.available2014-10-20T11:47:20Z-
dc.date.issued2013en_US
dc.identifier.citationJoint Annual Scientific Meeting 2013 of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 234en_US
dc.identifier.issn1013-9923-
dc.identifier.urihttp://hdl.handle.net/10722/206041-
dc.descriptionOral Presentation (Doctor’s Session)-
dc.descriptionFulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf-
dc.description.abstractHuman immunodeficiency virus (HIV) remains a major health problem around the globe, especially in third world countries where acquired immunodeficiency syndrome (AIDS) is highly prevalent and currently incurable. The HIV-1 trans-activator (Tat) protein is an important viral protein that is known to contribute to the AIDS pathogenesis via the dysregulation of cytokines such as TNF-α and IL- 6. In this study, we recognised that c-Myc, a proto-oncogene known to regulate a wide range of cellular process, also regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. We first found that HIV-1 Tat could induce the expression of c-Myc.The function and expression of HIV- 1 Tat induced c-Myc was subsequently found to be regulated through the activation of the dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). Inhibition of c-Myc expression in turn demonstrated that c-Myc may be essential for the up-regulation of the pro-inflammatory cytokines TNF-α and IL-6 by HIV-1 Tat. Furthermore, c-Myc regulation of HIV-1 Tat induced cytokine expression consequently affected the intracellular survival of the opportunistic microbe, Mycobacteria avium intracellulare, in PBMac. Taken together, we demonstrated that c-Myc may play a significant role in the pathogenesis of AIDS, by mediating the dysregulation of cytokine expression induced by Tat and possibly accentuate opportunistic infection.-
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp-
dc.relation.ispartofHong Kong Journal of Paediatrics (New series)en_US
dc.titleRegulation of HIV-Tat Induced Cytokine Expression and Consequent Opportunistic Infection by The Proto-Oncogene c-Mycen_US
dc.typeConference_Paperen_US
dc.identifier.emailPong, CH: jchpong@hku.hken_US
dc.identifier.emailLi, CB: jamesli@graduate.hku.hken_US
dc.identifier.emailLau, ASY: asylau@hku.hken_US
dc.identifier.authorityLi, CB=rp00496en_US
dc.identifier.authorityLau, ASY=rp00474en_US
dc.identifier.hkuros241312en_US
dc.identifier.volume18-
dc.identifier.issue4-
dc.identifier.spage234-
dc.identifier.epage234-
dc.publisher.placeHong Kong-

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