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Article: Current assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities

TitleCurrent assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities
Authors
Issue Date2013
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl
Citation
Future Virology, 2013, v. 8 n. 4, p. 405-419 How to Cite?
AbstractIn 2011, there were over 34 million people living with HIV infections, placing a heavy burden on public health sectors. HIV infection is a lifelong threat that cannot be prevented by vaccination or cured by antiretroviral drugs. The infected patients rely on daily antiretroviral therapy to suppress HIV viral replication. Hence, it is important to diagnose HIV infections as early as possible and to monitor the efficacy of antiretroviral therapy every 3–6 months. Different immunoassays detecting HIV antigens and antibodies have been modified to offer better sensitivity and more rapid diagnosis. Several clinical and virological parameters, including CD4+ cell counts, viral load and drug resistance mutations, are also used for treatment monitoring. Many molecular assay optimizations are now being utilized to improve patient care. This review will focus on the most updated HIV diagnostic assays, as well as discussing the upcoming possibilities of other advanced technologies.
Persistent Identifierhttp://hdl.handle.net/10722/205942
ISSN
2015 Impact Factor: 0.886
2015 SCImago Journal Rankings: 0.529
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTo, SWCen_US
dc.contributor.authorChen, JHKen_US
dc.contributor.authorYam, WCen_US
dc.date.accessioned2014-10-20T10:07:53Z-
dc.date.available2014-10-20T10:07:53Z-
dc.date.issued2013en_US
dc.identifier.citationFuture Virology, 2013, v. 8 n. 4, p. 405-419en_US
dc.identifier.issn1746-0794-
dc.identifier.urihttp://hdl.handle.net/10722/205942-
dc.description.abstractIn 2011, there were over 34 million people living with HIV infections, placing a heavy burden on public health sectors. HIV infection is a lifelong threat that cannot be prevented by vaccination or cured by antiretroviral drugs. The infected patients rely on daily antiretroviral therapy to suppress HIV viral replication. Hence, it is important to diagnose HIV infections as early as possible and to monitor the efficacy of antiretroviral therapy every 3–6 months. Different immunoassays detecting HIV antigens and antibodies have been modified to offer better sensitivity and more rapid diagnosis. Several clinical and virological parameters, including CD4+ cell counts, viral load and drug resistance mutations, are also used for treatment monitoring. Many molecular assay optimizations are now being utilized to improve patient care. This review will focus on the most updated HIV diagnostic assays, as well as discussing the upcoming possibilities of other advanced technologies.-
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl-
dc.relation.ispartofFuture Virologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCurrent assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilitiesen_US
dc.typeArticleen_US
dc.identifier.emailTo, SWC: sabtwc@hku.hken_US
dc.identifier.emailChen, JHK: jonchk@hku.hken_US
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hken_US
dc.identifier.authorityYam, WC=rp00313en_US
dc.description.naturepostprint-
dc.identifier.doi10.2217/fvl.13.21en_US
dc.identifier.scopuseid_2-s2.0-84876129528-
dc.identifier.hkuros240819en_US
dc.identifier.volume8en_US
dc.identifier.issue4-
dc.identifier.spage405en_US
dc.identifier.epage419en_US
dc.identifier.isiWOS:000317344000013-
dc.publisher.placeUnited Kingdom-

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