File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.2217/fvl.13.21
- Scopus: eid_2-s2.0-84876129528
- WOS: WOS:000317344000013
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Current assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities
Title | Current assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities |
---|---|
Authors | |
Keywords | determination drug resistance monitoring HIV-1 diagnostic assays tropism ultradeep sequencing viral load measurement |
Issue Date | 2013 |
Publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl |
Citation | Future Virology, 2013, v. 8 n. 4, p. 405-419 How to Cite? |
Abstract | In 2011, there were over 34 million people living with HIV infections, placing a heavy burden on public health sectors. HIV infection is a lifelong threat that cannot be prevented by vaccination or cured by antiretroviral drugs. The infected patients rely on daily antiretroviral therapy to suppress HIV viral replication. Hence, it is important to diagnose HIV infections as early as possible and to monitor the efficacy of antiretroviral therapy every 3–6 months. Different immunoassays detecting HIV antigens and antibodies have been modified to offer better sensitivity and more rapid diagnosis. Several clinical and virological parameters, including CD4+ cell counts, viral load and drug resistance mutations, are also used for treatment monitoring. Many molecular assay optimizations are now being utilized to improve patient care. This review will focus on the most updated HIV diagnostic assays, as well as discussing the upcoming possibilities of other advanced technologies. |
Persistent Identifier | http://hdl.handle.net/10722/205942 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.366 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | To, SWC | en_US |
dc.contributor.author | Chen, JHK | en_US |
dc.contributor.author | Yam, WC | en_US |
dc.date.accessioned | 2014-10-20T10:07:53Z | - |
dc.date.available | 2014-10-20T10:07:53Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Future Virology, 2013, v. 8 n. 4, p. 405-419 | en_US |
dc.identifier.issn | 1746-0794 | - |
dc.identifier.uri | http://hdl.handle.net/10722/205942 | - |
dc.description.abstract | In 2011, there were over 34 million people living with HIV infections, placing a heavy burden on public health sectors. HIV infection is a lifelong threat that cannot be prevented by vaccination or cured by antiretroviral drugs. The infected patients rely on daily antiretroviral therapy to suppress HIV viral replication. Hence, it is important to diagnose HIV infections as early as possible and to monitor the efficacy of antiretroviral therapy every 3–6 months. Different immunoassays detecting HIV antigens and antibodies have been modified to offer better sensitivity and more rapid diagnosis. Several clinical and virological parameters, including CD4+ cell counts, viral load and drug resistance mutations, are also used for treatment monitoring. Many molecular assay optimizations are now being utilized to improve patient care. This review will focus on the most updated HIV diagnostic assays, as well as discussing the upcoming possibilities of other advanced technologies. | - |
dc.language | eng | en_US |
dc.publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl | - |
dc.relation.ispartof | Future Virology | en_US |
dc.subject | determination | - |
dc.subject | drug resistance monitoring | - |
dc.subject | HIV-1 diagnostic assays | - |
dc.subject | tropism | - |
dc.subject | ultradeep sequencing | - |
dc.subject | viral load measurement | - |
dc.title | Current assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities | en_US |
dc.type | Article | en_US |
dc.identifier.email | To, SWC: sabtwc@hku.hk | en_US |
dc.identifier.email | Chen, JHK: jonchk@hku.hk | en_US |
dc.identifier.email | Yam, WC: wcyam@hkucc.hku.hk | en_US |
dc.identifier.authority | Yam, WC=rp00313 | en_US |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.2217/fvl.13.21 | en_US |
dc.identifier.scopus | eid_2-s2.0-84876129528 | - |
dc.identifier.hkuros | 240819 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 405 | en_US |
dc.identifier.epage | 419 | en_US |
dc.identifier.isi | WOS:000317344000013 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1746-0794 | - |