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Article: Distinct spatiotemporal expression of ISM1 during mouse and chick development

TitleDistinct spatiotemporal expression of ISM1 during mouse and chick development
Authors
Issue Date2014
Citation
Cell Cycle, 2014, v. 13 n. 10, p. 1571-1582 How to Cite?
AbstractIsthmin 1 (ISM1) constitutes the founder of a new family of secreted proteins characterized by the presence of 2 functional domains: thrombospondin type 1 repeat (TSR1) and adhesion-associated domain in MUC4 and other proteins (AMOP). ISM1 was identified in the frog embryo as a member of the FGF8 synexpression group due to its expression in the brain midbrain-hindbrain boundary (MHB) or isthmus. In zebrafish, ISM1 was described as a WNT- and NODAL-regulated gene. The function of ISM1 remains largely elusive. So far, ISM1 has been described as an angiogenesis inhibitor that has a dual function in endothelial cell survival and cell death. For a better understanding of ISM1 function, we examined its spatiotemporal distribution in mouse and chick using RT-PCR, ISH, and IHC analyses. In the mouse, ISM1 transcripts are found in tissues such as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain. In addition to its putative role during embryonic and postnatal development, ISM1 may also be important for organ homeostasis in the adult. In the chick embryo, ISM1 transcripts are strongly detected in the ear, eye, and spinal cord primordia. Remarkable differences in ISM1 spatiotemporal expression were found during mouse and chick development, despite the high homology of ISM1 orthologs in these species. © 2014 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/205897
ISSN
2015 Impact Factor: 3.952
2015 SCImago Journal Rankings: 2.244
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOsorio Da Silva, LAen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorZhou, Zen_US
dc.date.accessioned2014-10-20T09:25:29Z-
dc.date.available2014-10-20T09:25:29Z-
dc.date.issued2014en_US
dc.identifier.citationCell Cycle, 2014, v. 13 n. 10, p. 1571-1582en_US
dc.identifier.issn1538-4101-
dc.identifier.urihttp://hdl.handle.net/10722/205897-
dc.description.abstractIsthmin 1 (ISM1) constitutes the founder of a new family of secreted proteins characterized by the presence of 2 functional domains: thrombospondin type 1 repeat (TSR1) and adhesion-associated domain in MUC4 and other proteins (AMOP). ISM1 was identified in the frog embryo as a member of the FGF8 synexpression group due to its expression in the brain midbrain-hindbrain boundary (MHB) or isthmus. In zebrafish, ISM1 was described as a WNT- and NODAL-regulated gene. The function of ISM1 remains largely elusive. So far, ISM1 has been described as an angiogenesis inhibitor that has a dual function in endothelial cell survival and cell death. For a better understanding of ISM1 function, we examined its spatiotemporal distribution in mouse and chick using RT-PCR, ISH, and IHC analyses. In the mouse, ISM1 transcripts are found in tissues such as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain. In addition to its putative role during embryonic and postnatal development, ISM1 may also be important for organ homeostasis in the adult. In the chick embryo, ISM1 transcripts are strongly detected in the ear, eye, and spinal cord primordia. Remarkable differences in ISM1 spatiotemporal expression were found during mouse and chick development, despite the high homology of ISM1 orthologs in these species. © 2014 Landes Bioscience.-
dc.languageengen_US
dc.relation.ispartofCell Cycleen_US
dc.titleDistinct spatiotemporal expression of ISM1 during mouse and chick developmenten_US
dc.typeArticleen_US
dc.identifier.emailOsorio Da Silva, LA: losorio@hku.hken_US
dc.identifier.emailWu, X: xueweiwu@hkusua.hku.hken_US
dc.identifier.emailZhou, Z: zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4161/cc.28494en_US
dc.identifier.pmid24675886-
dc.identifier.pmcidPMC4050162-
dc.identifier.scopuseid_2-s2.0-84900553685-
dc.identifier.hkuros240877en_US
dc.identifier.volume13en_US
dc.identifier.spage1571en_US
dc.identifier.epage1582en_US
dc.identifier.isiWOS:000336661300014-

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