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Article: Calcifying tissue regeneration via biomimetic materials chemistry

TitleCalcifying tissue regeneration via biomimetic materials chemistry
Authors
Issue Date2014
PublisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572
Citation
Journal of the Royal Society. Interface, 2014, v. 11 n. 101, article no. 20140537 How to Cite?
AbstractMaterials chemistry is making a fundamental impact in regenerative sciences providing many platforms for tissue development. However, there is a surprising paucity of replacements that accurately mimic the structure and function of the structural fabric of tissues or promote faithful tissue reconstruction. Methodologies in biomimetic materials chemistry have shown promise in replicating morphologies, architectures and functional building blocks of acellular mineralized tissues dentine, enamel and bone or that can be used to fully regenerate them with integrated cell populations. Biomimetic materials chemistry encompasses the two processes of crystal formation and mineralization of crystals into inorganic formations on organic templates. This review will revisit the successes of biomimetics materials chemistry in regenerative medicine, including coccolithophore simulants able to promote in vivo bone formation. In-depth knowledge of biomineralization throughout evolution informs the biomimetic materials chemist of the most effective techniques for regenerative framework construction exemplified via exploitation of liquid crystals (LCs) and complex self-organizing media. Therefore, a new innovative direction would be to create chemical environments that perform reaction-diffusion exchanges as the basis for building complex biomimetic inorganic structures. This has evolved widely in biology, as have LCs, serving as self-organizing templates in pattern formation of structural biomaterials. For instance, a study is highlighted in which artificially fabricated chiral LCs, made from bacteriophages are transformed into a faithful copy of enamel. While chemical-based strategies are highly promising at creating new biomimetic structures there are limits to the degree of complexity that can be generated. Thus, there may be good reason to implement living or artificial cells in 'morphosynthesis' of complex inorganic constructs. In the future, cellular construction is probably key to instruct building of ultimate biomimetic hierarchies with a totality of functions. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/205887
ISSN
2015 Impact Factor: 3.818
2015 SCImago Journal Rankings: 1.622
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorGreen, DW-
dc.contributor.authorGoto, TK-
dc.contributor.authorJung, HS-
dc.date.accessioned2014-10-20T09:15:15Z-
dc.date.available2014-10-20T09:15:15Z-
dc.date.issued2014-
dc.identifier.citationJournal of the Royal Society. Interface, 2014, v. 11 n. 101, article no. 20140537-
dc.identifier.issn1742-5689-
dc.identifier.urihttp://hdl.handle.net/10722/205887-
dc.description.abstractMaterials chemistry is making a fundamental impact in regenerative sciences providing many platforms for tissue development. However, there is a surprising paucity of replacements that accurately mimic the structure and function of the structural fabric of tissues or promote faithful tissue reconstruction. Methodologies in biomimetic materials chemistry have shown promise in replicating morphologies, architectures and functional building blocks of acellular mineralized tissues dentine, enamel and bone or that can be used to fully regenerate them with integrated cell populations. Biomimetic materials chemistry encompasses the two processes of crystal formation and mineralization of crystals into inorganic formations on organic templates. This review will revisit the successes of biomimetics materials chemistry in regenerative medicine, including coccolithophore simulants able to promote in vivo bone formation. In-depth knowledge of biomineralization throughout evolution informs the biomimetic materials chemist of the most effective techniques for regenerative framework construction exemplified via exploitation of liquid crystals (LCs) and complex self-organizing media. Therefore, a new innovative direction would be to create chemical environments that perform reaction-diffusion exchanges as the basis for building complex biomimetic inorganic structures. This has evolved widely in biology, as have LCs, serving as self-organizing templates in pattern formation of structural biomaterials. For instance, a study is highlighted in which artificially fabricated chiral LCs, made from bacteriophages are transformed into a faithful copy of enamel. While chemical-based strategies are highly promising at creating new biomimetic structures there are limits to the degree of complexity that can be generated. Thus, there may be good reason to implement living or artificial cells in 'morphosynthesis' of complex inorganic constructs. In the future, cellular construction is probably key to instruct building of ultimate biomimetic hierarchies with a totality of functions. © 2014 The Author(s) Published by the Royal Society. All rights reserved.-
dc.languageeng-
dc.publisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572-
dc.relation.ispartofJournal of the Royal Society. Interface-
dc.titleCalcifying tissue regeneration via biomimetic materials chemistry-
dc.typeArticle-
dc.identifier.emailGreen, DW: dwgreen@hku.hk-
dc.identifier.emailGoto, TK: gototk@hku.hk-
dc.identifier.emailJung, HS: hsjung@hku.hk-
dc.identifier.authorityGreen, DW=rp01598-
dc.identifier.authorityGoto, TK=rp01434-
dc.identifier.authorityJung, HS=rp01683-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1098/rsif.2014.0537-
dc.identifier.pmid25320063-
dc.identifier.pmcidPMC4223895-
dc.identifier.hkuros241191-
dc.identifier.volume11-
dc.identifier.issue101-
dc.publisher.placeUnited Kingdom-

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