File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice

TitleEffects of melatonin, morphine and diazepam on formalin-induced nociception in mice
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2001, v. 68 n. 8, p. 943-951 How to Cite?
AbstractThe possible analgesic effect of melatonin was investigated in young male ICR mice. The formalin test which elicits typically 2 phases of pain response, the acute (first) phase and tonic (second) phase, was used. The test was performed in the late light period when the mice have been reported to be more sensitive to pain. Compared to control mice, no significant difference in nociceptive response was observed when melatonin was injected intraperitoneally at doses of 0.1, 5, and 20, mg/kg body weight. The combined effects of melatonin with diazepam and/or morphine, were also investigated. Melatonin, injected at 20 mg/kg 15 min before formalin test, significantly increased the antinociceptive response of diazepam (1 mg/kg) or morphine (5 mg/kg) in the second phase. In addition, when melatonin was given at 20 mg/kg together with diazepam and morphine, antinociceptive responses in both the first and second phase were increased. These data indicate the synergistic analgesia effect of melatonin with morphine and diazepam and suggest the possible involvement of melatonin as an adjunct medicine for pain patients.
Persistent Identifierhttp://hdl.handle.net/10722/205845
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, CS-
dc.contributor.authorTsang, SF-
dc.contributor.authorYang, JC-
dc.date.accessioned2014-10-14T06:56:56Z-
dc.date.available2014-10-14T06:56:56Z-
dc.date.issued2001-
dc.identifier.citationLife Sciences, 2001, v. 68 n. 8, p. 943-951-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/205845-
dc.description.abstractThe possible analgesic effect of melatonin was investigated in young male ICR mice. The formalin test which elicits typically 2 phases of pain response, the acute (first) phase and tonic (second) phase, was used. The test was performed in the late light period when the mice have been reported to be more sensitive to pain. Compared to control mice, no significant difference in nociceptive response was observed when melatonin was injected intraperitoneally at doses of 0.1, 5, and 20, mg/kg body weight. The combined effects of melatonin with diazepam and/or morphine, were also investigated. Melatonin, injected at 20 mg/kg 15 min before formalin test, significantly increased the antinociceptive response of diazepam (1 mg/kg) or morphine (5 mg/kg) in the second phase. In addition, when melatonin was given at 20 mg/kg together with diazepam and morphine, antinociceptive responses in both the first and second phase were increased. These data indicate the synergistic analgesia effect of melatonin with morphine and diazepam and suggest the possible involvement of melatonin as an adjunct medicine for pain patients.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.subject.meshAnalgesics - pharmacology-
dc.subject.meshDiazepam - pharmacology-
dc.subject.meshMelatonin - pharmacology-
dc.subject.meshMorphine - pharmacology-
dc.subject.meshNociceptors - drug effects-
dc.titleEffects of melatonin, morphine and diazepam on formalin-induced nociception in miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0024-3205(00)00996-6-
dc.identifier.pmid11213364-
dc.identifier.hkuros59162-
dc.identifier.volume68-
dc.identifier.issue8-
dc.identifier.spage943-
dc.identifier.epage951-
dc.identifier.isiWOS:000166536500010-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats