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Article: Review: Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?

TitleReview: Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?
Authors
Issue Date2012
Citation
Molecular Vision, 2012, v. 18, p. 2700-2710 How to Cite?
AbstractTau protein's versatility lies in its functions within the central nervous system, including protein scaffolding and intracellular signaling. Tauopathy has been one of the most extensively studied neuropathologies among the neurodegenerative diseases. Because the retina and optic nerve are parts of the central nervous system, we hypothesize that tauopathy also plays a role in various eye diseases. However, little is known about tauopathy in the retina and optic nerve. Here, we summarize the findings from histopathological studies on animal models and human specimens with distinct neurodegenerative diseases. Similar pathological changes of tau protein can be found in Alzheimer's disease, frontotemporal lobe dementia, and glaucoma. In view of the important roles of tauopathy in the brain, it is hoped that this review can stimulate research on eye diseases of the retina and optic nerve. © 2012 Molecular Vision.
Persistent Identifierhttp://hdl.handle.net/10722/205779
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, Winglau-
dc.contributor.authorLeung, Yen-
dc.contributor.authorTsang, Andrea Wing Ting-
dc.contributor.authorSo, Kwok Fai-
dc.contributor.authorChiu, Kin-
dc.contributor.authorChang, Raymond C C-
dc.date.accessioned2014-10-06T08:02:20Z-
dc.date.available2014-10-06T08:02:20Z-
dc.date.issued2012-
dc.identifier.citationMolecular Vision, 2012, v. 18, p. 2700-2710-
dc.identifier.urihttp://hdl.handle.net/10722/205779-
dc.description.abstractTau protein's versatility lies in its functions within the central nervous system, including protein scaffolding and intracellular signaling. Tauopathy has been one of the most extensively studied neuropathologies among the neurodegenerative diseases. Because the retina and optic nerve are parts of the central nervous system, we hypothesize that tauopathy also plays a role in various eye diseases. However, little is known about tauopathy in the retina and optic nerve. Here, we summarize the findings from histopathological studies on animal models and human specimens with distinct neurodegenerative diseases. Similar pathological changes of tau protein can be found in Alzheimer's disease, frontotemporal lobe dementia, and glaucoma. In view of the important roles of tauopathy in the brain, it is hoped that this review can stimulate research on eye diseases of the retina and optic nerve. © 2012 Molecular Vision.-
dc.languageeng-
dc.relation.ispartofMolecular Vision-
dc.titleReview: Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid23170062-
dc.identifier.scopuseid_2-s2.0-84870047040-
dc.identifier.volume18-
dc.identifier.spage2700-
dc.identifier.epage2710-
dc.identifier.eissn1090-0535-
dc.identifier.isiWOS:000312241300004-

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