File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Quantitative analysis of fiber tractography in cervical spondylotic myelopathy

TitleQuantitative analysis of fiber tractography in cervical spondylotic myelopathy
Authors
KeywordsCervical spondylotic myelopathy
Diffusion tensor imaging
Fiber tractography
Spinal cord
Issue Date2013
Citation
Spine Journal, 2013, v. 13, n. 6, p. 697-705 How to Cite?
AbstractBackground context: Diffusion tensor fiber tractography is an emerging tool for the visualization of spinal cord microstructure. However, there are few quantitative analyses of the damage in the nerve fiber tracts of the myelopathic spinal cord. Purpose: The aim of this study was to develop a quantitative approach for fiber tractography analysis in cervical spondylotic myelopathy (CSM). Study design/setting: Prospective study on a series of patients. Materials and methods: A total of 22 volunteers were recruited with informed consent, including 15 healthy subjects and 7 CSM patients. The clinical severity of CSM was evaluated using modified Japanese Orthopedic Association (JOA) score. The microstructure of myelopathic cervical cord was analyzed using diffusion tensor imaging. Diffusion tensor imaging was performed with a 3.0-T magnetic resonance imaging scanner using pulsed gradient, spin-echo, echo-planar imaging sequence. Fiber tractography was generated via TrackVis with fractional anisotropy threshold set at 0.2 and angle threshold at 40. Region of interest (ROI) was defined to cover C4 level only or the whole-length cervical spinal cord from C1 to C7 for analysis. The length and density of tracked nerve bundles were measured for comparison between healthy subjects and CSM patients. Results: The length of tracked nerve bundles significantly shortened in CSM patients compared with healthy subjects (healthy: 6.85-77.90 mm, CSM: 0.68-62.53 mm). The density of the tracked nerve bundles was also lower in CSM patients (healthy: 086±0.03, CSM: 0.80±0.06, p<.05). Although the definition of ROI covering C4 only or whole cervical cord appeared not to affect the trend of the disparity between healthy and myelopathic cervical cords, the density of the tracked nerve bundle through whole myelopathic cords was in an association with the modified JOA score in CSM cases (r=0.949, p=.015), yet not found with ROI at C4 only (r=0.316, p=.684). Conclusions: The quantitative analysis of fiber tractography is a reliable approach to detect cervical spondylotic myelopathic lesions compared with healthy spinal cords. It could be employed to delineate the severity of CSM. © 2013 Published by Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/205716
ISSN
2015 Impact Factor: 2.66
2015 SCImago Journal Rankings: 1.153
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWen, Chunyi-
dc.contributor.authorCui, Jiaolong-
dc.contributor.authorLee, Manpan-
dc.contributor.authorMak, Kincheung-
dc.contributor.authorLuk, KeithDK-
dc.contributor.authorHu, Yong-
dc.date.accessioned2014-10-06T08:02:15Z-
dc.date.available2014-10-06T08:02:15Z-
dc.date.issued2013-
dc.identifier.citationSpine Journal, 2013, v. 13, n. 6, p. 697-705-
dc.identifier.issn1529-9430-
dc.identifier.urihttp://hdl.handle.net/10722/205716-
dc.description.abstractBackground context: Diffusion tensor fiber tractography is an emerging tool for the visualization of spinal cord microstructure. However, there are few quantitative analyses of the damage in the nerve fiber tracts of the myelopathic spinal cord. Purpose: The aim of this study was to develop a quantitative approach for fiber tractography analysis in cervical spondylotic myelopathy (CSM). Study design/setting: Prospective study on a series of patients. Materials and methods: A total of 22 volunteers were recruited with informed consent, including 15 healthy subjects and 7 CSM patients. The clinical severity of CSM was evaluated using modified Japanese Orthopedic Association (JOA) score. The microstructure of myelopathic cervical cord was analyzed using diffusion tensor imaging. Diffusion tensor imaging was performed with a 3.0-T magnetic resonance imaging scanner using pulsed gradient, spin-echo, echo-planar imaging sequence. Fiber tractography was generated via TrackVis with fractional anisotropy threshold set at 0.2 and angle threshold at 40. Region of interest (ROI) was defined to cover C4 level only or the whole-length cervical spinal cord from C1 to C7 for analysis. The length and density of tracked nerve bundles were measured for comparison between healthy subjects and CSM patients. Results: The length of tracked nerve bundles significantly shortened in CSM patients compared with healthy subjects (healthy: 6.85-77.90 mm, CSM: 0.68-62.53 mm). The density of the tracked nerve bundles was also lower in CSM patients (healthy: 086±0.03, CSM: 0.80±0.06, p<.05). Although the definition of ROI covering C4 only or whole cervical cord appeared not to affect the trend of the disparity between healthy and myelopathic cervical cords, the density of the tracked nerve bundle through whole myelopathic cords was in an association with the modified JOA score in CSM cases (r=0.949, p=.015), yet not found with ROI at C4 only (r=0.316, p=.684). Conclusions: The quantitative analysis of fiber tractography is a reliable approach to detect cervical spondylotic myelopathic lesions compared with healthy spinal cords. It could be employed to delineate the severity of CSM. © 2013 Published by Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofSpine Journal-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in The Spine Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Spine Journal, 2013, v. 13 n. 6, p. 697-705. DOI: 10.1016/j.spinee.2013.02.061-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCervical spondylotic myelopathy-
dc.subjectDiffusion tensor imaging-
dc.subjectFiber tractography-
dc.subjectSpinal cord-
dc.titleQuantitative analysis of fiber tractography in cervical spondylotic myelopathy-
dc.typeArticle-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.spinee.2013.02.061-
dc.identifier.pmid23623632-
dc.identifier.scopuseid_2-s2.0-84878788308-
dc.identifier.hkuros220322-
dc.identifier.volume13-
dc.identifier.issue6-
dc.identifier.spage697-
dc.identifier.epage705-
dc.identifier.eissn1878-1632-
dc.identifier.isiWOS:000320595200014-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats