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Article: Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside

TitleNeurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Authors
Issue Date2013
PublisherElsevier Ltd.. The Journal's web site is located at http://www.elsevier.com/locate/pneurobio
Citation
Progress in Neurobiology, 2013, v. 115, p. 116-137 How to Cite?
AbstractResearchers who have uncovered the presence of stem cells in an adult's central nervous system have not only challenged the dogma that new neurons cannot be generated during adulthood, but also shed light on the etiology and disease mechanisms underlying many neurological and psychiatric disorders. Brain trauma, neurodegenerative diseases, and psychiatric disorders pose enormous burdens at both personal and societal levels. Although medications for these disorders are widely used, the treatment mechanisms underlying the illnesses remain largely elusive. In the past decade, an increasing amount of evidence indicate that adult neurogenesis (i.e. generating new CNS neurons during adulthood) may be involved in the pathology of different CNS disorders, and thus neurogenesis may be a potential target area for treatments. Although new neurons were shown to be a major player in mediating treatment efficacy of neurological and psychotropic drugs on cognitive functions, it is still debatable if the altered production of new neurons can cause the disorders. This review hence seeks to discuss pre and current clinical studies that demonstrate the functional impact adult neurogenesis have on neurological and psychiatric illnesses while examining the related underlying disease mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/205581
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_US
dc.contributor.authorRuan, Len_US
dc.contributor.authorLau, BWMen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorHuang, Len_US
dc.contributor.authorZhuGe, Qen_US
dc.contributor.authorWang, Ben_US
dc.contributor.authorJin, Ken_US
dc.date.accessioned2014-09-20T04:00:24Z-
dc.date.available2014-09-20T04:00:24Z-
dc.date.issued2013en_US
dc.identifier.citationProgress in Neurobiology, 2013, v. 115, p. 116-137en_US
dc.identifier.urihttp://hdl.handle.net/10722/205581-
dc.description.abstractResearchers who have uncovered the presence of stem cells in an adult's central nervous system have not only challenged the dogma that new neurons cannot be generated during adulthood, but also shed light on the etiology and disease mechanisms underlying many neurological and psychiatric disorders. Brain trauma, neurodegenerative diseases, and psychiatric disorders pose enormous burdens at both personal and societal levels. Although medications for these disorders are widely used, the treatment mechanisms underlying the illnesses remain largely elusive. In the past decade, an increasing amount of evidence indicate that adult neurogenesis (i.e. generating new CNS neurons during adulthood) may be involved in the pathology of different CNS disorders, and thus neurogenesis may be a potential target area for treatments. Although new neurons were shown to be a major player in mediating treatment efficacy of neurological and psychotropic drugs on cognitive functions, it is still debatable if the altered production of new neurons can cause the disorders. This review hence seeks to discuss pre and current clinical studies that demonstrate the functional impact adult neurogenesis have on neurological and psychiatric illnesses while examining the related underlying disease mechanisms.en_US
dc.languageengen_US
dc.publisherElsevier Ltd.. The Journal's web site is located at http://www.elsevier.com/locate/pneurobioen_US
dc.relation.ispartofProgress in Neurobiologyen_US
dc.titleNeurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedsideen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.doi10.1016/j.pneurobio.2013.12.006en_US
dc.identifier.pmid24384539-
dc.identifier.hkuros239758en_US
dc.identifier.volume115en_US
dc.identifier.spage116en_US
dc.identifier.epage137en_US
dc.identifier.isiWOS:000334084100007-

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