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Article: Limbal Stem Cells and Corneal Epithelial Regeneration: Current Status and Prospectives

TitleLimbal Stem Cells and Corneal Epithelial Regeneration: Current Status and Prospectives
Authors
KeywordsCorneal structure
Limbal stem cell
Cell-based transplantation
Regeneration of corneal epithelium
Issue Date2014
PublisherAvens Publishing Group.
Citation
Journal of Ocular Biology, 2014, v. 2 n. 1, p. article no. 10 How to Cite?
AbstractThe clear cornea functions like a window that controls the entry of light for visual information and plays a protective role. The failure of appropriate repair following corneal injury results in loss of corneal function. The limbal region of the cornea is thought to serve as a unique reservoir of corneal epithelial stem cells where limbal stem cells (LSC) contributed to the regeneration of corneal epithelium. The deficiency of LSC (LSCD) results in the failed regeneration of corneal epithelium following injuries. In this review, we discuss the current knowledge of LSC and LSC-based transplantation for regeneration of corneal epithelium. We will first review the latest development of corneal structures. Next we will introduce the concept of LSC and the associated debates. Third, we will review different LSC-based transplantation methods for LSCD treatment and compare their advantages and disadvantages. Finally, we will discuss the improvements of regeneration of corneal epithelium.
Persistent Identifierhttp://hdl.handle.net/10722/205576
ISSN

 

DC FieldValueLanguage
dc.contributor.authorYan, Len_US
dc.contributor.authorJiang, Den_US
dc.contributor.authorHe, Jen_US
dc.contributor.authorWong, DSHen_US
dc.contributor.authorLian, Qen_US
dc.date.accessioned2014-09-20T04:00:23Z-
dc.date.available2014-09-20T04:00:23Z-
dc.date.issued2014-
dc.identifier.citationJournal of Ocular Biology, 2014, v. 2 n. 1, p. article no. 10en_US
dc.identifier.issn2334-2838-
dc.identifier.urihttp://hdl.handle.net/10722/205576-
dc.description.abstractThe clear cornea functions like a window that controls the entry of light for visual information and plays a protective role. The failure of appropriate repair following corneal injury results in loss of corneal function. The limbal region of the cornea is thought to serve as a unique reservoir of corneal epithelial stem cells where limbal stem cells (LSC) contributed to the regeneration of corneal epithelium. The deficiency of LSC (LSCD) results in the failed regeneration of corneal epithelium following injuries. In this review, we discuss the current knowledge of LSC and LSC-based transplantation for regeneration of corneal epithelium. We will first review the latest development of corneal structures. Next we will introduce the concept of LSC and the associated debates. Third, we will review different LSC-based transplantation methods for LSCD treatment and compare their advantages and disadvantages. Finally, we will discuss the improvements of regeneration of corneal epithelium.en_US
dc.languageengen_US
dc.publisherAvens Publishing Group.en_US
dc.relation.ispartofJournal of Ocular Biologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCorneal structure-
dc.subjectLimbal stem cell-
dc.subjectCell-based transplantation-
dc.subjectRegeneration of corneal epithelium-
dc.titleLimbal Stem Cells and Corneal Epithelial Regeneration: Current Status and Prospectivesen_US
dc.typeArticleen_US
dc.identifier.emailYan, L: ylmeng@hku.hken_US
dc.identifier.emailHe, J: hejiajia@hku.hken_US
dc.identifier.emailWong, DSH: shdwong@hku.hken_US
dc.identifier.emailLian, Q: qzlian@hkucc.hku.hken_US
dc.identifier.authorityWong, DSH=rp00516en_US
dc.identifier.authorityLian, Q=rp00267en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros239259en_US
dc.identifier.volume2en_US
dc.identifier.issue1en_US
dc.identifier.spagearticle no. 10-
dc.identifier.epagearticle no. 10-
dc.publisher.placeUnited States-

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