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Article: Update on Apoptosis Signal Pathway of Retinal Ganglion Cell

TitleUpdate on Apoptosis Signal Pathway of Retinal Ganglion Cell
视网膜神经节细胞凋亡的信号通路研究进展
Authors
KeywordsRetinal ganglion cells - pathology
Apoptosis - induced factor, gene
Signal transduction
Neuroprotection - drug
Issue Date2014
Publisher中华医学会. The Journal's web site is located at http://c.g.wanfangdata.com.cn/Periodical-ykyj.aspx
Citation
中华实验眼科杂志, 2014, v. 32 n. 4, p. 359-364 How to Cite?
Chinese Journal of Experimental Ophthalmology, 2014, v. 32 n. 4, p. 359-364 How to Cite?
Abstract视网膜神经节细胞(RGCs)的进行性凋亡是许多视网膜病变和视神经疾病进展到最后的必经之路,是多种眼病致盲的根本原因.RGCs对外界因素的影响异常敏感,外伤、高眼压、炎症和神经毒素等均可造成其不可逆的损伤,而这些细胞外信号又通过不同的途径影响着细胞内部的信号转导,调节细胞内凋亡相关基因的表达,最终造成RGCs的凋亡.本文从细胞外部因素的诱导、细胞内部的信号传递和基因调控3个方面总结病理情况下RGCs凋亡信号转导通路研究的最新进展,旨在为视网膜神经保护药物的开发提供新的思路.
Persistent Identifierhttp://hdl.handle.net/10722/205563
ISSN
2015 SCImago Journal Rankings: 0.106

 

DC FieldValueLanguage
dc.contributor.authorWang, Wen_US
dc.contributor.authorChen, Len_US
dc.date.accessioned2014-09-20T04:00:21Z-
dc.date.available2014-09-20T04:00:21Z-
dc.date.issued2014en_US
dc.identifier.citation中华实验眼科杂志, 2014, v. 32 n. 4, p. 359-364en_US
dc.identifier.citationChinese Journal of Experimental Ophthalmology, 2014, v. 32 n. 4, p. 359-364-
dc.identifier.issn2095-0160-
dc.identifier.urihttp://hdl.handle.net/10722/205563-
dc.description.abstract视网膜神经节细胞(RGCs)的进行性凋亡是许多视网膜病变和视神经疾病进展到最后的必经之路,是多种眼病致盲的根本原因.RGCs对外界因素的影响异常敏感,外伤、高眼压、炎症和神经毒素等均可造成其不可逆的损伤,而这些细胞外信号又通过不同的途径影响着细胞内部的信号转导,调节细胞内凋亡相关基因的表达,最终造成RGCs的凋亡.本文从细胞外部因素的诱导、细胞内部的信号传递和基因调控3个方面总结病理情况下RGCs凋亡信号转导通路研究的最新进展,旨在为视网膜神经保护药物的开发提供新的思路.-
dc.languagechien_US
dc.publisher中华医学会. The Journal's web site is located at http://c.g.wanfangdata.com.cn/Periodical-ykyj.aspx-
dc.relation.ispartof中华实验眼科杂志en_US
dc.relation.ispartofChinese Journal of Experimental Ophthalmology-
dc.subjectRetinal ganglion cells - pathology-
dc.subjectApoptosis - induced factor, gene-
dc.subjectSignal transduction-
dc.subjectNeuroprotection - drug-
dc.titleUpdate on Apoptosis Signal Pathway of Retinal Ganglion Cellen_US
dc.title视网膜神经节细胞凋亡的信号通路研究进展-
dc.typeArticleen_US
dc.identifier.emailChen, L: lchen98@hku.hken_US
dc.identifier.authorityChen, L=rp01865en_US
dc.identifier.doi10.3760/cma.j.issn.2095-0160.2014.04.017-
dc.identifier.hkuros237203en_US
dc.identifier.volume32-
dc.identifier.issue4-
dc.identifier.spage359-
dc.identifier.epage364-
dc.publisher.placeChina-

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