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Conference Paper: An investigation of the association between retinal detachment and oral fluoroquinolones: A self-controlled case series study

TitleAn investigation of the association between retinal detachment and oral fluoroquinolones: A self-controlled case series study
Authors
Issue Date2013
PublisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62
Citation
The 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 151 How to Cite?
AbstractAim/Objective: To investigate the association between oral fl uoroquinolones (FQ) and retinal detachment (RD) and to estimate the absolute risk of developing RD in patients exposed to oral FQ. Methods: We performed a self-controlled case series study on Hong Kong, Taiwanese and British patients who had prescription(s) of oral FQ and RD procedure code(s) during 2001-2012; 2000-2010; and 1994-2012 respectively. Records were retrieved from the Hong Kong Clinical Data Analysis and Reporting System database, the Taiwan National Health Insurance Research Database and the United Kingdom IMS Disease Analyzer Database. Incidence rate ratios (IRR) are derived, by comparing the rate of RD during FQ exposed and non-exposed periods. Results: A total of 1,516,566 FQ prescriptions were prescribed to 836,249 patients. There were 455, 1002, 861 cases in Hong Kong, Taiwan and United Kingdom respectively. A total of 13 events were found during the FQ exposed period; and 2,305 during the non-exposed period. The adjusted IRR for patients in Hong Kong, Taiwan and United Kingdom were 1.16 (95%CI 0.36-3.75), 1.70 (0.84-3.46) and 0.65 (0.16-2.63) respectively. In the combined model, there was no statistically signifi cant association with an adjusted IRR of 1.27 (0.73-2.21). The crude absolute risk of RD whilst on oral FQ was approximately 1 per 150,000 prescriptions. Conclusion: Our study does not support the association between the use of FQ and RD. Therefore, the use of FQ should not be precluded based on the current evidence on the risk of RD. However, a further study is warranted to investigate this controversial association.
DescriptionOral Presentation: Cardiovascular Issues and Antibiotics
Conference Theme: Applying pharmacoepidemiology to improve health care in Asia
Persistent Identifierhttp://hdl.handle.net/10722/205559
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChui, SLCen_US
dc.contributor.authorMan, KCKen_US
dc.contributor.authorCheng, CLen_US
dc.contributor.authorChan, EWen_US
dc.contributor.authorLau, CYen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorWong, DSHen_US
dc.contributor.authorYang-Kao, YHen_US
dc.contributor.authorWong, ICKen_US
dc.date.accessioned2014-09-20T03:54:36Z-
dc.date.available2014-09-20T03:54:36Z-
dc.date.issued2013en_US
dc.identifier.citationThe 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 151en_US
dc.identifier.issn1727-2874-
dc.identifier.urihttp://hdl.handle.net/10722/205559-
dc.descriptionOral Presentation: Cardiovascular Issues and Antibiotics-
dc.descriptionConference Theme: Applying pharmacoepidemiology to improve health care in Asia-
dc.description.abstractAim/Objective: To investigate the association between oral fl uoroquinolones (FQ) and retinal detachment (RD) and to estimate the absolute risk of developing RD in patients exposed to oral FQ. Methods: We performed a self-controlled case series study on Hong Kong, Taiwanese and British patients who had prescription(s) of oral FQ and RD procedure code(s) during 2001-2012; 2000-2010; and 1994-2012 respectively. Records were retrieved from the Hong Kong Clinical Data Analysis and Reporting System database, the Taiwan National Health Insurance Research Database and the United Kingdom IMS Disease Analyzer Database. Incidence rate ratios (IRR) are derived, by comparing the rate of RD during FQ exposed and non-exposed periods. Results: A total of 1,516,566 FQ prescriptions were prescribed to 836,249 patients. There were 455, 1002, 861 cases in Hong Kong, Taiwan and United Kingdom respectively. A total of 13 events were found during the FQ exposed period; and 2,305 during the non-exposed period. The adjusted IRR for patients in Hong Kong, Taiwan and United Kingdom were 1.16 (95%CI 0.36-3.75), 1.70 (0.84-3.46) and 0.65 (0.16-2.63) respectively. In the combined model, there was no statistically signifi cant association with an adjusted IRR of 1.27 (0.73-2.21). The crude absolute risk of RD whilst on oral FQ was approximately 1 per 150,000 prescriptions. Conclusion: Our study does not support the association between the use of FQ and RD. Therefore, the use of FQ should not be precluded based on the current evidence on the risk of RD. However, a further study is warranted to investigate this controversial association.-
dc.languageengen_US
dc.publisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62-
dc.relation.ispartofHong Kong Pharmaceutical Journalen_US
dc.titleAn investigation of the association between retinal detachment and oral fluoroquinolones: A self-controlled case series studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailChui, SLC: cslchui@hku.hken_US
dc.identifier.emailMan, KCK: mkckth@hku.hken_US
dc.identifier.emailChan, EW: ewchan@hku.hken_US
dc.identifier.emailLau, CY: wallisy@hku.hken_US
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hken_US
dc.identifier.emailWong, DSH: shdwong@hku.hken_US
dc.identifier.emailWong, ICK: wongick@hku.hken_US
dc.identifier.authorityChan, EW=rp01587en_US
dc.identifier.authorityWong, DSH=rp00516en_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.identifier.hkuros239901en_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage151en_US
dc.identifier.epage151en_US
dc.publisher.placeHong Kong-

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