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Article: Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus

TitleConservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus
Authors
Issue Date2014
Citation
Virologica Sinica, 2014, v. 29 n. 3, p. 170-175 How to Cite?
AbstractA novel avian influenza A (H7N9) virus recently emerged in the Yangtze River delta and caused diseases, often severe, in over 130 people. This H7N9 virus appeared to infect humans with greater ease than previous avian influenza virus subtypes such as H5N1 and H9N2. While there are other potential explanations for this large number of human infections with an avian influenza virus, we investigated whether a lack of conserved T-cell epitopes between endemic H1N1 and H3N2 influenza viruses and the novel H7N9 virus contributes to this observation. Here we demonstrate that a number of T cell epitopes are conserved between endemic H1N1 and H3N2 viruses and H7N9 virus. Most of these conserved epitopes are from viral internal proteins. The extent of conservation between endemic human seasonal influenza and avian influenza H7N9 was comparable to that with the highly pathogenic avian influenza H5N1. Thus, the ease of inter-species transmission of H7N9 viruses (compared with avian H5N1 viruses) cannot be attributed to the lack of conservation of such T cell epitopes. On the contrary, our findings predict significant T-cell based cross-reactions in the human population to the novel H7N9 virus. Our findings also have implications for H7N9 virus vaccine design.
Persistent Identifierhttp://hdl.handle.net/10722/205473

 

DC FieldValueLanguage
dc.contributor.authorMao, Hen_US
dc.contributor.authorYen, Hen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorLau, YLen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorTu, Wen_US
dc.date.accessioned2014-09-20T02:36:20Z-
dc.date.available2014-09-20T02:36:20Z-
dc.date.issued2014en_US
dc.identifier.citationVirologica Sinica, 2014, v. 29 n. 3, p. 170-175en_US
dc.identifier.urihttp://hdl.handle.net/10722/205473-
dc.description.abstractA novel avian influenza A (H7N9) virus recently emerged in the Yangtze River delta and caused diseases, often severe, in over 130 people. This H7N9 virus appeared to infect humans with greater ease than previous avian influenza virus subtypes such as H5N1 and H9N2. While there are other potential explanations for this large number of human infections with an avian influenza virus, we investigated whether a lack of conserved T-cell epitopes between endemic H1N1 and H3N2 influenza viruses and the novel H7N9 virus contributes to this observation. Here we demonstrate that a number of T cell epitopes are conserved between endemic H1N1 and H3N2 viruses and H7N9 virus. Most of these conserved epitopes are from viral internal proteins. The extent of conservation between endemic human seasonal influenza and avian influenza H7N9 was comparable to that with the highly pathogenic avian influenza H5N1. Thus, the ease of inter-species transmission of H7N9 viruses (compared with avian H5N1 viruses) cannot be attributed to the lack of conservation of such T cell epitopes. On the contrary, our findings predict significant T-cell based cross-reactions in the human population to the novel H7N9 virus. Our findings also have implications for H7N9 virus vaccine design.en_US
dc.languageengen_US
dc.relation.ispartofVirologica Sinicaen_US
dc.titleConservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virusen_US
dc.typeArticleen_US
dc.identifier.emailMao, H: hwmau@hku.hken_US
dc.identifier.emailYen, H: hyen@hku.hken_US
dc.identifier.emailLiu, Y: yinpingl@hku.hken_US
dc.identifier.emailLau, YL: lauylung@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailTu, W: wwtu@hku.hken_US
dc.identifier.authorityMao, H=rp01595en_US
dc.identifier.authorityYen, H=rp00304en_US
dc.identifier.authorityLiu, Y=rp00269en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityTu, W=rp00416en_US
dc.identifier.doi10.1007/s12250-014-3473-3en_US
dc.identifier.hkuros238637en_US
dc.identifier.hkuros244598-
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.spage170en_US
dc.identifier.epage175en_US

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