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Article: The effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009–2013

TitleThe effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009–2013
Authors
Issue Date2014
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2014, v. 32 n. 41, p. 5278-5284 How to Cite?
AbstractBACKGROUND: Influenza vaccination is widely recommended every year to protect individuals against influenza virus infection and illness. There are few published estimates of influenza vaccine effectiveness against hospitalization in children or from subtropical regions. METHODS: We conducted a test-negative year-round study between October 2009 and September 2013, recruiting children 6months to 17years of age admitted to two hospitals in Hong Kong with a febrile acute respiratory infection. Cases were tested for influenza A and B and conditional logistic regression was used to estimate vaccine effectiveness comparing influenza vaccination history of the trivalent influenza vaccine (TIV) among patients testing positive versus negative for influenza, adjusting for age and sex and matching by calendar week of recruitment. RESULTS: Overall vaccine effectiveness against hospitalization with laboratory-confirmed influenza A and B was estimated to be 61.7% (95% CI: 43.0%, 74.2%). The estimated vaccine effectiveness against A(H3N2) was 36.6% (95% CI: -25.5%, 67.9%) compared to 71.5% (95% CI: 39.4%, 86.6%) for A(H1N1)pdm09 and 68.8% (95% CI: 41.6%, 83.3%) for B. CONCLUSIONS: Vaccine effectiveness against hospitalization in children varied from year to year, but was moderate to high overall even in an area with influenza activity throughout the year.
Persistent Identifierhttp://hdl.handle.net/10722/205472
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCowling, BJ-
dc.contributor.authorChan, KH-
dc.contributor.authorFeng, S-
dc.contributor.authorChan, LY-
dc.contributor.authorLo, JYC-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorChiu, SSS-
dc.date.accessioned2014-09-20T02:36:20Z-
dc.date.available2014-09-20T02:36:20Z-
dc.date.issued2014-
dc.identifier.citationVaccine, 2014, v. 32 n. 41, p. 5278-5284-
dc.identifier.issn0264-410X-
dc.identifier.urihttp://hdl.handle.net/10722/205472-
dc.description.abstractBACKGROUND: Influenza vaccination is widely recommended every year to protect individuals against influenza virus infection and illness. There are few published estimates of influenza vaccine effectiveness against hospitalization in children or from subtropical regions. METHODS: We conducted a test-negative year-round study between October 2009 and September 2013, recruiting children 6months to 17years of age admitted to two hospitals in Hong Kong with a febrile acute respiratory infection. Cases were tested for influenza A and B and conditional logistic regression was used to estimate vaccine effectiveness comparing influenza vaccination history of the trivalent influenza vaccine (TIV) among patients testing positive versus negative for influenza, adjusting for age and sex and matching by calendar week of recruitment. RESULTS: Overall vaccine effectiveness against hospitalization with laboratory-confirmed influenza A and B was estimated to be 61.7% (95% CI: 43.0%, 74.2%). The estimated vaccine effectiveness against A(H3N2) was 36.6% (95% CI: -25.5%, 67.9%) compared to 71.5% (95% CI: 39.4%, 86.6%) for A(H1N1)pdm09 and 68.8% (95% CI: 41.6%, 83.3%) for B. CONCLUSIONS: Vaccine effectiveness against hospitalization in children varied from year to year, but was moderate to high overall even in an area with influenza activity throughout the year.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine-
dc.relation.ispartofVaccine-
dc.titleThe effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009–2013-
dc.typeArticle-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailFeng, S: elainefs@hku.hk-
dc.identifier.emailChan, LY: laiyin@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailChiu, SSS: ssschiu@hku.hk-
dc.identifier.authorityCowling, BJ=rp01326en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityChiu, SSS=rp00421en_US
dc.identifier.doi10.1016/j.vaccine.2014.07.084-
dc.identifier.pmid25092636-
dc.identifier.pmcidPMC4165553-
dc.identifier.hkuros238454-
dc.identifier.volume32-
dc.identifier.issue41-
dc.identifier.spage5278-
dc.identifier.epage5284-
dc.identifier.isiWOS:000342272400004-
dc.publisher.placeUnited Kingdom-

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