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Conference Paper: Repeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats

TitleRepeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats
Authors
Issue Date2014
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Experimental Biology (EB), San Diego, California, USA, 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. Suppl. 1, p. abstract no. LB559 How to Cite?
AbstractNon-invasive Remote ischemic preconditioning (NRIPC) has a cardioprotective effect in normal rats, but its effect in rats with diabetes is controversial. This study was mainly to determine the cardioprotective effect of NRIPC on ischemia reperfusion injury (IRI) in diabetic rats. Diabetes was induced in Sprague-Dawley rats with streptozotocin. NRIPC was implemented by applying 3 cycles of 5-min occlusion/5-min reperfusion in a unilateral hindlimb once per day for three days. The animals were then subjected to 30 minutes of coronary artery occlusion followed by two hours of reperfusion. A control group had no NRIPC. The results showed that NRIPC significantly reduced post-ischemic myocardial infarct size,lactate dehydrogenase (LDH) and troponin-1 release during reperfusion in both control and diabetic rats. Protein PKC-ε, phosphorylation of AKT and signal transducer and activator of transcription 3(STAT3) were all significantly increased after NRIPC and their enhancement after reperfusion was correlated with reductions of post-ischemic myocardial infarction and cellular injury. In conclusion, cardioprotection can be achieved in diabetes by NRIPC applied repeatedly for three days prior to inducing myocardial infarction and activation of PKC-ε and STAT3 might be a major mechanism of NRIPC protection.
DescriptionConference Theme: Transforming the Future through Science
Session: Pharmacology and Experimental Therapeutics - Cardiovascular Pharmacology
Persistent Identifierhttp://hdl.handle.net/10722/204767
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorXia, Zen_US
dc.contributor.authorIrwin, MGen_US
dc.date.accessioned2014-09-20T00:39:20Z-
dc.date.available2014-09-20T00:39:20Z-
dc.date.issued2014en_US
dc.identifier.citationExperimental Biology (EB), San Diego, California, USA, 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. Suppl. 1, p. abstract no. LB559en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/204767-
dc.descriptionConference Theme: Transforming the Future through Science-
dc.descriptionSession: Pharmacology and Experimental Therapeutics - Cardiovascular Pharmacology-
dc.description.abstractNon-invasive Remote ischemic preconditioning (NRIPC) has a cardioprotective effect in normal rats, but its effect in rats with diabetes is controversial. This study was mainly to determine the cardioprotective effect of NRIPC on ischemia reperfusion injury (IRI) in diabetic rats. Diabetes was induced in Sprague-Dawley rats with streptozotocin. NRIPC was implemented by applying 3 cycles of 5-min occlusion/5-min reperfusion in a unilateral hindlimb once per day for three days. The animals were then subjected to 30 minutes of coronary artery occlusion followed by two hours of reperfusion. A control group had no NRIPC. The results showed that NRIPC significantly reduced post-ischemic myocardial infarct size,lactate dehydrogenase (LDH) and troponin-1 release during reperfusion in both control and diabetic rats. Protein PKC-ε, phosphorylation of AKT and signal transducer and activator of transcription 3(STAT3) were all significantly increased after NRIPC and their enhancement after reperfusion was correlated with reductions of post-ischemic myocardial infarction and cellular injury. In conclusion, cardioprotection can be achieved in diabetes by NRIPC applied repeatedly for three days prior to inducing myocardial infarction and activation of PKC-ε and STAT3 might be a major mechanism of NRIPC protection.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.titleRepeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Ratsen_US
dc.typeConference_Paperen_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.identifier.authorityIrwin, MG=rp00390en_US
dc.identifier.hkuros235644en_US
dc.identifier.volume28en_US
dc.identifier.issueSuppl. 1en_US
dc.publisher.placeUnited States-

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