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Conference Paper: Leukotriene receptor antagonists and suicide: a self-controlled case series study

TitleLeukotriene receptor antagonists and suicide: a self-controlled case series study
Authors
Issue Date2013
PublisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62
Citation
The 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 141 How to Cite?
AbstractAim/Objective: In March 2008 the suicide of a 15 year old boy captured media attention. The suicide was attributed to the exposure of montelukast, a leukotriene receptor antagonist (LTRA) used to treat asthma and allergies. The presence of, unknown and unmeasured confounders are limitations in observational studies, particularly in the study of suicide which has several risk factors. The self-controlled case series (SCCS) method automatically controls for fi xed confounders. Objectives: To investigate the association of suicide and LTRAs using the SCCS method in the UK. Method: Electronic healthcare records of patients with a record of suicide attempt (including suicide and self -harm, poisoning-selfinfl icted, injury–self infl icted, cause of overdose-deliberate) and exposure to LTRAs during the period of 1st January 1998 to 1st January 2011 were extracted from the Health Improvement Network (THIN) database of anonymised records from contributing UK general practices. A risk period of thirty days before and after exposure to LTRA and control periods within the observation time of each patient were identifi ed. A Poisson analysis conditioned on the event was used to calculate the Incidence Rate Ratio (IRR). Results: A total of 236 cases of fi rst attempts of suicide were identifi ed. The IRR for a risk period of 30 days after the start of treatment with LTRA was 0.32 (95% CI 0.04-2.42; P=0.268). Conclusion: Our study does not support the association between the use of LTRA and suicide attempts within the fi rst thirty days of exposure to LTRA. Further studies with larger number of cases are needed.
DescriptionConference Theme: Applying pharmacoepidemiology to improve health care in Asia
Oral Presentation - Paediatrics – Mental and General Health
Persistent Identifierhttp://hdl.handle.net/10722/204452
ISSN

 

DC FieldValueLanguage
dc.contributor.authorIessa, Nen_US
dc.contributor.authorMurray, MLen_US
dc.contributor.authorMan, KCKen_US
dc.date.accessioned2014-09-19T23:52:22Z-
dc.date.available2014-09-19T23:52:22Z-
dc.date.issued2013en_US
dc.identifier.citationThe 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 141en_US
dc.identifier.issn1727-2874-
dc.identifier.urihttp://hdl.handle.net/10722/204452-
dc.descriptionConference Theme: Applying pharmacoepidemiology to improve health care in Asia-
dc.descriptionOral Presentation - Paediatrics – Mental and General Health-
dc.description.abstractAim/Objective: In March 2008 the suicide of a 15 year old boy captured media attention. The suicide was attributed to the exposure of montelukast, a leukotriene receptor antagonist (LTRA) used to treat asthma and allergies. The presence of, unknown and unmeasured confounders are limitations in observational studies, particularly in the study of suicide which has several risk factors. The self-controlled case series (SCCS) method automatically controls for fi xed confounders. Objectives: To investigate the association of suicide and LTRAs using the SCCS method in the UK. Method: Electronic healthcare records of patients with a record of suicide attempt (including suicide and self -harm, poisoning-selfinfl icted, injury–self infl icted, cause of overdose-deliberate) and exposure to LTRAs during the period of 1st January 1998 to 1st January 2011 were extracted from the Health Improvement Network (THIN) database of anonymised records from contributing UK general practices. A risk period of thirty days before and after exposure to LTRA and control periods within the observation time of each patient were identifi ed. A Poisson analysis conditioned on the event was used to calculate the Incidence Rate Ratio (IRR). Results: A total of 236 cases of fi rst attempts of suicide were identifi ed. The IRR for a risk period of 30 days after the start of treatment with LTRA was 0.32 (95% CI 0.04-2.42; P=0.268). Conclusion: Our study does not support the association between the use of LTRA and suicide attempts within the fi rst thirty days of exposure to LTRA. Further studies with larger number of cases are needed.-
dc.languageengen_US
dc.publisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62-
dc.relation.ispartofHong Kong Pharmaceutical Journalen_US
dc.titleLeukotriene receptor antagonists and suicide: a self-controlled case series studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailMan, KCK: mkckth@hku.hken_US
dc.identifier.hkuros239879en_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage141en_US
dc.identifier.epage141en_US
dc.publisher.placeHong Kong-

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