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Conference Paper: Drug utilisation patterns in hospitalised children: An international perspective

TitleDrug utilisation patterns in hospitalised children: An international perspective
Authors
Keywordsdrug utilisation
paediatric
international
Issue Date2013
PublisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62
Citation
The 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 140 How to Cite?
AbstractAim/Objective: The majority of published drug utilisation studies in children come from primary care. Our aim was to investigate and compare patterns of drug therapy in hospitalised children in fi ve European and Non-European countries using a standardised protocol and terminologies. Methods: A prospective cohort study was conducted on paediatric medical wards in UK, Germany, Australia, Hong Kong (HK), and Malaysia. Drugs prescribed were classifi ed using WHO Anatomical Therapeutic Chemical (ATC) classifi cation. The frequency of prescriptions and exposure rates were calculated at ATC anatomic and therapeutic levels overall and stratifi ed by country. Results: 1278 patients were included (Australia 146, Germany 376, UK 313, HK 143, Malaysia 300). 1140 patients (89.2%) received 5367 prescriptions, median 3 per patient (IQR 2-5). The three most frequently prescribed therapeutic groups were; systemic antibacterials [1355 (25.3%), exposure (65.1%)], analgesics/ NSAIDs [1172 (21.8%), exposure (63.6%)], ‘drugs for obstructive airway diseases’ [472 (8.8%), exposure (23.6%)]. Number of patients exposed to these groups differed signifi cantly between countries p<0.05. Patients’ exposure to systemic antibacterials was highest in Malaysia (84.7%), lowest in HK (37.1%). Patients’ exposure to analgesics/NSAIDs varied signifi cantly between countries being highest in UK (84.2%,) and lowest in HK (35,3%), p<0.001. Paracetamol was the most frequent analgesic/NSAID in 4 countries. Metamizol was only prescribed in Germany whereas morphine was predominantly prescribed in the UK. Conclusion: This study shows that there are similarities but also signifi cant differences in drug utilisation patterns in hospitalised children across countries. Rational drug therapy has to be further investigated and promoted in paediatric medicine.
DescriptionConference Theme: Applying pharmacoepidemiology to improve health care in Asia
Oral Presentation - Genetics, Pregnancy and Paediatric Issues
Persistent Identifierhttp://hdl.handle.net/10722/204451
ISSN

 

DC FieldValueLanguage
dc.contributor.authorRashed, ANen_US
dc.contributor.authorWilton, Len_US
dc.contributor.authorTomlin, Sen_US
dc.contributor.authorWong, ICKen_US
dc.contributor.authorNeubert, Aen_US
dc.date.accessioned2014-09-19T23:52:22Z-
dc.date.available2014-09-19T23:52:22Z-
dc.date.issued2013en_US
dc.identifier.citationThe 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 140en_US
dc.identifier.issn1727-2874-
dc.identifier.urihttp://hdl.handle.net/10722/204451-
dc.descriptionConference Theme: Applying pharmacoepidemiology to improve health care in Asia-
dc.descriptionOral Presentation - Genetics, Pregnancy and Paediatric Issues-
dc.description.abstractAim/Objective: The majority of published drug utilisation studies in children come from primary care. Our aim was to investigate and compare patterns of drug therapy in hospitalised children in fi ve European and Non-European countries using a standardised protocol and terminologies. Methods: A prospective cohort study was conducted on paediatric medical wards in UK, Germany, Australia, Hong Kong (HK), and Malaysia. Drugs prescribed were classifi ed using WHO Anatomical Therapeutic Chemical (ATC) classifi cation. The frequency of prescriptions and exposure rates were calculated at ATC anatomic and therapeutic levels overall and stratifi ed by country. Results: 1278 patients were included (Australia 146, Germany 376, UK 313, HK 143, Malaysia 300). 1140 patients (89.2%) received 5367 prescriptions, median 3 per patient (IQR 2-5). The three most frequently prescribed therapeutic groups were; systemic antibacterials [1355 (25.3%), exposure (65.1%)], analgesics/ NSAIDs [1172 (21.8%), exposure (63.6%)], ‘drugs for obstructive airway diseases’ [472 (8.8%), exposure (23.6%)]. Number of patients exposed to these groups differed signifi cantly between countries p<0.05. Patients’ exposure to systemic antibacterials was highest in Malaysia (84.7%), lowest in HK (37.1%). Patients’ exposure to analgesics/NSAIDs varied signifi cantly between countries being highest in UK (84.2%,) and lowest in HK (35,3%), p<0.001. Paracetamol was the most frequent analgesic/NSAID in 4 countries. Metamizol was only prescribed in Germany whereas morphine was predominantly prescribed in the UK. Conclusion: This study shows that there are similarities but also signifi cant differences in drug utilisation patterns in hospitalised children across countries. Rational drug therapy has to be further investigated and promoted in paediatric medicine.-
dc.languageengen_US
dc.publisherThe Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62-
dc.relation.ispartofHong Kong Pharmaceutical Journalen_US
dc.subjectdrug utilisation-
dc.subjectpaediatric-
dc.subjectinternational-
dc.titleDrug utilisation patterns in hospitalised children: An international perspectiveen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, ICK: wongick@hku.hken_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.identifier.hkuros239877en_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage140en_US
dc.identifier.epage140en_US
dc.publisher.placeHong Kong-

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