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Conference Paper: Serotonergic control of synaptic transmission in rat medial vestibular nucleus

TitleSerotonergic control of synaptic transmission in rat medial vestibular nucleus
Authors
Issue Date2014
PublisherBlackwell Publishing Ltd.
Citation
The 12th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Kaohsiung, Taiwan, 23–26 August 2014. In Journal of Neurochemistry, 2014, v. 130 n. Suppl. 1, p. 29, abstract no. YIC03-1 How to Cite?
AbstractTo address the role of serotonergic projections from dorsal raphe nucleus to the medial vestibular nucleus (MV), whole-cell patchclamp was employed to investigate the serotonergic modulation of spontaneous synaptic transmission within the MV of rats. Perfusion of serotonin (5-hydroxytryptamine, 5-HT) to brainstem slices robustly facilitated both spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) in a subgroup of MV neurons. That this enhancement effect of 5-HT on sIPSCs and sEPSCs were both abolished with tetrodotoxin indicates that 5-HT acts on its receptor that expressed in the presynaptic neurons. Using different receptor antagonists, we further identified that GABAA and glycine receptors took part in the enhancement effect on sIPSCs whereas AMPA receptor was involved in sEPSCs. This 5-HT-induced effect on both sIPSCs and sEPSCs could be mimicked with application of 5-HT2 receptor agonist but was blocked with 5-HT2A receptor antagonist. Our results therefore indicate that within the MV, 5-HT2A receptors expressed on presynaptic neurons function to facilitate both inhibitory and excitatory transmission that allows the potentiation of targeted synapses.
DescriptionYoung Investigator Colloquium 3
Persistent Identifierhttp://hdl.handle.net/10722/204411
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021

 

DC FieldValueLanguage
dc.contributor.authorHan, Len_US
dc.contributor.authorLai, SKen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2014-09-19T23:34:42Z-
dc.date.available2014-09-19T23:34:42Z-
dc.date.issued2014en_US
dc.identifier.citationThe 12th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Kaohsiung, Taiwan, 23–26 August 2014. In Journal of Neurochemistry, 2014, v. 130 n. Suppl. 1, p. 29, abstract no. YIC03-1en_US
dc.identifier.issn0022-3042-
dc.identifier.urihttp://hdl.handle.net/10722/204411-
dc.descriptionYoung Investigator Colloquium 3-
dc.description.abstractTo address the role of serotonergic projections from dorsal raphe nucleus to the medial vestibular nucleus (MV), whole-cell patchclamp was employed to investigate the serotonergic modulation of spontaneous synaptic transmission within the MV of rats. Perfusion of serotonin (5-hydroxytryptamine, 5-HT) to brainstem slices robustly facilitated both spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) in a subgroup of MV neurons. That this enhancement effect of 5-HT on sIPSCs and sEPSCs were both abolished with tetrodotoxin indicates that 5-HT acts on its receptor that expressed in the presynaptic neurons. Using different receptor antagonists, we further identified that GABAA and glycine receptors took part in the enhancement effect on sIPSCs whereas AMPA receptor was involved in sEPSCs. This 5-HT-induced effect on both sIPSCs and sEPSCs could be mimicked with application of 5-HT2 receptor agonist but was blocked with 5-HT2A receptor antagonist. Our results therefore indicate that within the MV, 5-HT2A receptors expressed on presynaptic neurons function to facilitate both inhibitory and excitatory transmission that allows the potentiation of targeted synapses.-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd.-
dc.relation.ispartofJournal of Neurochemistryen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleSerotonergic control of synaptic transmission in rat medial vestibular nucleusen_US
dc.typeConference_Paperen_US
dc.identifier.emailHan, L: rahanlei@hku.hken_US
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hken_US
dc.identifier.authorityLai, CH=rp00396en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/jnc.12776-
dc.identifier.hkuros238259en_US
dc.identifier.volume130-
dc.identifier.issueSuppl. 1-
dc.identifier.spage29, abstract no. YIC03-1-
dc.identifier.epage29, abstract no. YIC03-1-
dc.publisher.placeUnited Kingdom-

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