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Conference Paper: Body Mass Index and its Association with Lumbar Disc Herniation and Sciatica: A Large-Scale, Population-Based Study

TitleBody Mass Index and its Association with Lumbar Disc Herniation and Sciatica: A Large-Scale, Population-Based Study
Authors
Issue Date2014
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53
Citation
World Forum for Spine Research (WFSR), Xi'an, China,15-17 May 2014. In Global Spine Journal, 2014, v. 4 n. Suppl. 1, p. S46, abstract no. PO.019 How to Cite?
AbstractIntroduction Elevated body mass index (BMI) or overweight and obesity are pandemics. Lumbar disc herniation and sciatica occur in every population and present severe socioeconomic consequences. However, little is known regarding the role of BMI with lumbar disc herniation and sciatica. As such, the following large-scale study addressed the association of BMI, in particular overweight and obesity, with disc herniation, its global lumbar involvement and its implications with the development of sciatica. Materials and Methods A cross-sectional study of 2,596 Southern Chinese (mean age: 42 years; 60% females) was conducted assessing T2-weighted MRI, environmental and lifestyle factors, as well as clinical profiles of sciatica. On imaging, the presence of disc bulge/ extrusion (DBE) and other spinal phenotypes from L1-S1were assessed. Disc degenerationwas assessed and graded based on the Schneiderman et al criteria and summated of all levels to produce a degenerative disc disease (DDD) score (potential score range: 0-15). A total DBE (TDBE) score of L1-S1 was calculated (potential score range: 0-10). Asian-modified BMI values and categories of underweight, normal weight, overweight, and obese were obtained for each subject. Results DBEwas noted in 46.3% of the subjects, mainly occurring at L4- S1. The mean DDD and TDBE scores were 0.7 and 2.83, respectively. Historical prevalence of sciatica was 44.6%, with 17.9% reporting sciatica at the time of assessment. The mean BMI was 22.9 kg/m2 (7.2% underweight, 47.9% normal weight, 36.1% overweight, and 8.9% obese). Elevated DDD scorewas significantly correlated with an elevated TDBE score (r¼0.610; p< 0.001). TDBE score significantly increased with elevated BMI categories (p< 0.001). Multivariate analyses adjusting for covariates noted that elevated BMI was significantly associated with DBE (normalweight [Ref]; underweight OR: 0.71[95% CI: 0.49-1.03]; overweight OR: 1.26[95% CI: 1.04-1.52]; obese OR: 1.78[95% CI: 1.30-2.44]). TDBE score (OR: 1.36; 95% CI: 1.15-1.60) and obesity (OR: 1.68; 95% CI: 1.25-2.24) were significantly related with sciatica. Worse functional and disability scores were associated with sciatica (p< 0.05). Conclusion Based on the largest population-based study to assess the role of BMI and its association with disc herniation, this study definitely noted that overweight and obesity significantly increased the likelihood of having lumbar disc herniation, its global severity, and the risk of developing sciatica. Disclosure of Interest None declared
DescriptionConference theme: The Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation
Poster presentation
The abstract can be viewed at http://www.spineresearchforum.org/WFSR_2014_Thieme_AbstractBook_with_Cover.pdf
Persistent Identifierhttp://hdl.handle.net/10722/204388
ISSN
2015 SCImago Journal Rankings: 0.108

 

DC FieldValueLanguage
dc.contributor.authorSamartzis, Den_US
dc.contributor.authorKarppinen, JIen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorCheung, KMCen_US
dc.date.accessioned2014-09-19T22:41:29Z-
dc.date.available2014-09-19T22:41:29Z-
dc.date.issued2014en_US
dc.identifier.citationWorld Forum for Spine Research (WFSR), Xi'an, China,15-17 May 2014. In Global Spine Journal, 2014, v. 4 n. Suppl. 1, p. S46, abstract no. PO.019en_US
dc.identifier.issn2192-5682-
dc.identifier.urihttp://hdl.handle.net/10722/204388-
dc.descriptionConference theme: The Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation-
dc.descriptionPoster presentation-
dc.descriptionThe abstract can be viewed at http://www.spineresearchforum.org/WFSR_2014_Thieme_AbstractBook_with_Cover.pdf-
dc.description.abstractIntroduction Elevated body mass index (BMI) or overweight and obesity are pandemics. Lumbar disc herniation and sciatica occur in every population and present severe socioeconomic consequences. However, little is known regarding the role of BMI with lumbar disc herniation and sciatica. As such, the following large-scale study addressed the association of BMI, in particular overweight and obesity, with disc herniation, its global lumbar involvement and its implications with the development of sciatica. Materials and Methods A cross-sectional study of 2,596 Southern Chinese (mean age: 42 years; 60% females) was conducted assessing T2-weighted MRI, environmental and lifestyle factors, as well as clinical profiles of sciatica. On imaging, the presence of disc bulge/ extrusion (DBE) and other spinal phenotypes from L1-S1were assessed. Disc degenerationwas assessed and graded based on the Schneiderman et al criteria and summated of all levels to produce a degenerative disc disease (DDD) score (potential score range: 0-15). A total DBE (TDBE) score of L1-S1 was calculated (potential score range: 0-10). Asian-modified BMI values and categories of underweight, normal weight, overweight, and obese were obtained for each subject. Results DBEwas noted in 46.3% of the subjects, mainly occurring at L4- S1. The mean DDD and TDBE scores were 0.7 and 2.83, respectively. Historical prevalence of sciatica was 44.6%, with 17.9% reporting sciatica at the time of assessment. The mean BMI was 22.9 kg/m2 (7.2% underweight, 47.9% normal weight, 36.1% overweight, and 8.9% obese). Elevated DDD scorewas significantly correlated with an elevated TDBE score (r¼0.610; p< 0.001). TDBE score significantly increased with elevated BMI categories (p< 0.001). Multivariate analyses adjusting for covariates noted that elevated BMI was significantly associated with DBE (normalweight [Ref]; underweight OR: 0.71[95% CI: 0.49-1.03]; overweight OR: 1.26[95% CI: 1.04-1.52]; obese OR: 1.78[95% CI: 1.30-2.44]). TDBE score (OR: 1.36; 95% CI: 1.15-1.60) and obesity (OR: 1.68; 95% CI: 1.25-2.24) were significantly related with sciatica. Worse functional and disability scores were associated with sciatica (p< 0.05). Conclusion Based on the largest population-based study to assess the role of BMI and its association with disc herniation, this study definitely noted that overweight and obesity significantly increased the likelihood of having lumbar disc herniation, its global severity, and the risk of developing sciatica. Disclosure of Interest None declared-
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53-
dc.relation.ispartofGlobal Spine Journalen_US
dc.rightsGlobal Spine Journal. Copyright © Georg Thieme Verlag.-
dc.titleBody Mass Index and its Association with Lumbar Disc Herniation and Sciatica: A Large-Scale, Population-Based Studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailSamartzis, D: dspine@hku.hken_US
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_US
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_US
dc.identifier.authoritySamartzis, D=rp01430en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.hkuros238042en_US
dc.identifier.volume4-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS46, abstract no. PO.019-
dc.identifier.epageS46, abstract no. PO.019-
dc.publisher.placeGermanyen_US

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