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Conference Paper: Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice

TitleHeterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice
Authors
Issue Date2013
PublisherET-13 International Conference.
Citation
The 13th International Conference on Endothelin (ET-13), Tokyo, Japan, 8-11 September 2013. In ET-13 Program & Abstracts, 2013, p. 53, abstract O-5 How to Cite?
AbstractCirculating levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. The renal artery is important in controlling intrarenal blood # ow and is highly sensitive to ET-1. Whether or not ET-1 affects renal artery tone in obesity is unknown. To investigate the role of endogenous ET-1, a mouse model with tie-1 promoter-driven endothelium-restricted heterozygous overexpression of preproendothelin-1 was used (TET+/-). Obesity was induced in TET+/- and WT littermates by feeding a high fat diet ...
DescriptionSession 3: Renal Diseases: O-5
Persistent Identifierhttp://hdl.handle.net/10722/203720

 

DC FieldValueLanguage
dc.contributor.authorBaretella, OMen_US
dc.contributor.authorChung, SKen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2014-09-19T16:11:29Z-
dc.date.available2014-09-19T16:11:29Z-
dc.date.issued2013en_US
dc.identifier.citationThe 13th International Conference on Endothelin (ET-13), Tokyo, Japan, 8-11 September 2013. In ET-13 Program & Abstracts, 2013, p. 53, abstract O-5en_US
dc.identifier.urihttp://hdl.handle.net/10722/203720-
dc.descriptionSession 3: Renal Diseases: O-5-
dc.description.abstractCirculating levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. The renal artery is important in controlling intrarenal blood # ow and is highly sensitive to ET-1. Whether or not ET-1 affects renal artery tone in obesity is unknown. To investigate the role of endogenous ET-1, a mouse model with tie-1 promoter-driven endothelium-restricted heterozygous overexpression of preproendothelin-1 was used (TET+/-). Obesity was induced in TET+/- and WT littermates by feeding a high fat diet ...-
dc.languageengen_US
dc.publisherET-13 International Conference.-
dc.relation.ispartofET-13 Program & Abstracts 2013en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHeterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese miceen_US
dc.typeConference_Paperen_US
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.authorityChung, SK=rp00381en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturepostprint-
dc.identifier.hkuros238784en_US
dc.identifier.spage53-
dc.identifier.epage53-
dc.publisher.placeJapan-

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