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Article: Confidence-interval construction for rate ratio in matched-pair studies with incomplete data

TitleConfidence-interval construction for rate ratio in matched-pair studies with incomplete data
Authors
Issue Date2014
PublisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10543406.asp
Citation
Journal of Biopharmaceutical Statistics, 2014, v. 24 n. 3, p. 546-568 How to Cite?
AbstractMatched-pair design is often used in clinical trials to increase the efficiency of establishing equivalence between two treatments with binary outcomes. In this article, we consider such a design based on rate ratio in the presence of incomplete data. The rate ratio is one of the most frequently used indices in comparing efficiency of two treatments in clinical trials. In this article, we propose 10 confidence-interval estimators for the rate ratio in incomplete matched-pair designs. A hybrid method that recovers variance estimates required for the rate ratio from the confidence limits for single proportions is proposed. It is noteworthy that confidence intervals based on this hybrid method have closed-form solution. The performance of the proposed confidence intervals is evaluated with respect to their exact coverage probability, expected confidence interval width, and distal and mesial noncoverage probability. The results show that the hybrid Agresti–Coull confidence interval based on Fieller’s theorem performs satisfactorily for small to moderate sample sizes. Two real examples from clinical trials are used to illustrate the proposed confidence intervals.
Persistent Identifierhttp://hdl.handle.net/10722/203437

 

DC FieldValueLanguage
dc.contributor.authorLi, HQen_US
dc.contributor.authorChan, ISFen_US
dc.contributor.authorTang, MLen_US
dc.contributor.authorTian, Gen_US
dc.contributor.authorTang, NSen_US
dc.date.accessioned2014-09-19T15:10:31Z-
dc.date.available2014-09-19T15:10:31Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Biopharmaceutical Statistics, 2014, v. 24 n. 3, p. 546-568en_US
dc.identifier.urihttp://hdl.handle.net/10722/203437-
dc.description.abstractMatched-pair design is often used in clinical trials to increase the efficiency of establishing equivalence between two treatments with binary outcomes. In this article, we consider such a design based on rate ratio in the presence of incomplete data. The rate ratio is one of the most frequently used indices in comparing efficiency of two treatments in clinical trials. In this article, we propose 10 confidence-interval estimators for the rate ratio in incomplete matched-pair designs. A hybrid method that recovers variance estimates required for the rate ratio from the confidence limits for single proportions is proposed. It is noteworthy that confidence intervals based on this hybrid method have closed-form solution. The performance of the proposed confidence intervals is evaluated with respect to their exact coverage probability, expected confidence interval width, and distal and mesial noncoverage probability. The results show that the hybrid Agresti–Coull confidence interval based on Fieller’s theorem performs satisfactorily for small to moderate sample sizes. Two real examples from clinical trials are used to illustrate the proposed confidence intervals.-
dc.languageengen_US
dc.publisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10543406.aspen_US
dc.relation.ispartofJournal of Biopharmaceutical Statisticsen_US
dc.rightsThis is an electronic version of an article published in Journal of Biopharmaceutical Statistics, 2014, v. 24 n. 3, p. 546-568. The article is available online at: http://www.tandfonline.com/doi/abs/10.1080/10543406.2014.888438-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleConfidence-interval construction for rate ratio in matched-pair studies with incomplete dataen_US
dc.typeArticleen_US
dc.identifier.emailTian, G: gltian@hku.hken_US
dc.identifier.authorityTian, G=rp00789en_US
dc.description.naturepostprint-
dc.identifier.doi10.1080/10543406.2014.888438en_US
dc.identifier.hkuros240190en_US
dc.identifier.volume24en_US
dc.identifier.issue3en_US
dc.identifier.spage546en_US
dc.identifier.epage568en_US

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