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Book Chapter: Reactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction

TitleReactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction
Authors
Issue Date2014
PublisherSpringer
Citation
Reactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction. In Laher, I (Ed.), Systems Biology of Free Radicals and Antioxidants, v. 2, p. 1325-1342 . Heidelberg: Springer, 2014 How to Cite?
AbstractThe augmented release of endothelium-derived contracting factor(s) is a hallmark of endothelial dysfunction. The most common endothelium-derived contracting factors (EDCFs) are produced by endothelial cyclooxygenase(s) and cause activation of thromboxane-prostanoid (TP) receptors of the underlying vascular smooth muscle cells. Endothelium-dependent contractions are exacerbated by aging, endothelial regeneration, hypertension, and diabetes. Elevated oxidative stress and the resulting increased production of reactive oxygen species (ROS) are key aspects of cardiovascular disease and play an important role in the occurrence and/or modulation of endothelium-dependent contraction. This present review summarizes the current knowledge on the interactions between ROS and EDCF in the genesis of endothelial dysfunction in animals and humans as a therapeutic target to restore proper endothelial function and slow down the progression of vascular disease.
Persistent Identifierhttp://hdl.handle.net/10722/203294
ISBN

 

DC FieldValueLanguage
dc.contributor.authorShi, Yen_US
dc.contributor.authorVanhoutte, PMGRen_US
dc.date.accessioned2014-09-19T13:56:10Z-
dc.date.available2014-09-19T13:56:10Z-
dc.date.issued2014en_US
dc.identifier.citationReactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction. In Laher, I (Ed.), Systems Biology of Free Radicals and Antioxidants, v. 2, p. 1325-1342 . Heidelberg: Springer, 2014en_US
dc.identifier.isbn978-3-642-30017-2-
dc.identifier.urihttp://hdl.handle.net/10722/203294-
dc.description.abstractThe augmented release of endothelium-derived contracting factor(s) is a hallmark of endothelial dysfunction. The most common endothelium-derived contracting factors (EDCFs) are produced by endothelial cyclooxygenase(s) and cause activation of thromboxane-prostanoid (TP) receptors of the underlying vascular smooth muscle cells. Endothelium-dependent contractions are exacerbated by aging, endothelial regeneration, hypertension, and diabetes. Elevated oxidative stress and the resulting increased production of reactive oxygen species (ROS) are key aspects of cardiovascular disease and play an important role in the occurrence and/or modulation of endothelium-dependent contraction. This present review summarizes the current knowledge on the interactions between ROS and EDCF in the genesis of endothelial dysfunction in animals and humans as a therapeutic target to restore proper endothelial function and slow down the progression of vascular disease.-
dc.languageengen_US
dc.publisherSpringer-
dc.relation.ispartofSystems Biology of Free Radicals and Antioxidantsen_US
dc.titleReactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunctionen_US
dc.typeBook_Chapteren_US
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PMGR=rp00238en_US
dc.identifier.doi10.1007/978-3-642-30018-9_74en_US
dc.identifier.hkuros238766en_US
dc.identifier.volume2en_US
dc.identifier.spage1325en_US
dc.identifier.epage1342en_US
dc.publisher.placeHeidelberg-

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