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Article: Electrostatics in pharmaceutical solids

TitleElectrostatics in pharmaceutical solids
Authors
Issue Date2015
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ces
Citation
Chemical Engineering Science, 2015, v. 125, p. 225-237 How to Cite?
AbstractPharmaceutical solids are likely to accumulate electrostatic charge through handling processes encountered both in industry and during clinical use. Important advances in the past decade have continued to improve our understanding and enabled better control of electrostatics. Although certain areas have been studied more extensively than others, much remains unexplored at the fundamental level and in vivo deposition studies are required to confirm the impact of charged aerosols in humans. This review has summarised the key fundamentals, highlighted the relevance in industrial and clinical settings, evaluated the factors that influence charging and discussed measurement techniques with regards to pharmaceutical powders. The understanding gained could potentially have regulatory implications, and could assist in the development and manufacture of pharmaceutical powders and their delivery systems. © 2014 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/203286
ISSN
2015 Impact Factor: 2.75
2015 SCImago Journal Rankings: 1.073

 

DC FieldValueLanguage
dc.contributor.authorWong, J-
dc.contributor.authorKwok, PCL-
dc.contributor.authorChan, HK-
dc.date.accessioned2014-09-19T13:56:09Z-
dc.date.available2014-09-19T13:56:09Z-
dc.date.issued2015-
dc.identifier.citationChemical Engineering Science, 2015, v. 125, p. 225-237-
dc.identifier.issn0009-2509-
dc.identifier.urihttp://hdl.handle.net/10722/203286-
dc.description.abstractPharmaceutical solids are likely to accumulate electrostatic charge through handling processes encountered both in industry and during clinical use. Important advances in the past decade have continued to improve our understanding and enabled better control of electrostatics. Although certain areas have been studied more extensively than others, much remains unexplored at the fundamental level and in vivo deposition studies are required to confirm the impact of charged aerosols in humans. This review has summarised the key fundamentals, highlighted the relevance in industrial and clinical settings, evaluated the factors that influence charging and discussed measurement techniques with regards to pharmaceutical powders. The understanding gained could potentially have regulatory implications, and could assist in the development and manufacture of pharmaceutical powders and their delivery systems. © 2014 Elsevier B.V.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ces-
dc.relation.ispartofChemical Engineering Science-
dc.titleElectrostatics in pharmaceutical solids-
dc.typeArticle-
dc.identifier.emailKwok, PCL: pclkwok@hku.hk-
dc.identifier.emailChan, HK: kimchan1@hku.hk-
dc.identifier.authorityKwok, PCL=rp01540-
dc.identifier.doi10.1016/j.ces.2014.05.037-
dc.identifier.scopuseid_2-s2.0-84922232903-
dc.identifier.hkuros236954-
dc.identifier.volume125-
dc.identifier.spage225-
dc.identifier.epage237-
dc.publisher.placeUnited Kingdom-

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