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Article: Immune cascades in human intervertebral disc: the pros and cons

TitleImmune cascades in human intervertebral disc: the pros and cons
Authors
Issue Date2013
PublisherE-Century Publishing Corporation. The Journal's web site is located at http://www.ijcep.com
Citation
International Journal of Clinical and Experimental Pathology, 2013, v. 6 n. 6, p. 1009-1014 How to Cite?
AbstractThe unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP.
Persistent Identifierhttp://hdl.handle.net/10722/203242
ISSN
2015 Impact Factor: 1.581
2015 SCImago Journal Rankings: 0.617
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, Zen_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorZhao, XHen_US
dc.contributor.authorLiu, ZHen_US
dc.contributor.authorGao, Yen_US
dc.contributor.authorSamartzis, Den_US
dc.contributor.authorWang, HQen_US
dc.contributor.authorLuo, ZJen_US
dc.date.accessioned2014-09-19T13:11:29Z-
dc.date.available2014-09-19T13:11:29Z-
dc.date.issued2013en_US
dc.identifier.citationInternational Journal of Clinical and Experimental Pathology, 2013, v. 6 n. 6, p. 1009-1014en_US
dc.identifier.issn1936-2625en_US
dc.identifier.urihttp://hdl.handle.net/10722/203242-
dc.description.abstractThe unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP.en_US
dc.languageengen_US
dc.publisherE-Century Publishing Corporation. The Journal's web site is located at http://www.ijcep.com-
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleImmune cascades in human intervertebral disc: the pros and consen_US
dc.typeArticleen_US
dc.identifier.emailSamartzis, D: dspine@hku.hken_US
dc.identifier.authoritySamartzis, D=rp01430en_US
dc.description.naturepublished_or_final_version-
dc.identifier.pmid23696917-
dc.identifier.pmcidPMC3657352-
dc.identifier.hkuros237997en_US
dc.identifier.hkuros256015-
dc.identifier.volume6en_US
dc.identifier.issue6en_US
dc.identifier.spage1009en_US
dc.identifier.epage1014en_US
dc.identifier.isiWOS:000324306400002-

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