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Article: Dynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infection

TitleDynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infection
Authors
Issue Date2014
Citation
J Infect, 2014 How to Cite?
AbstractTcytokineo investigate peripheral blood lymphocyte subgroups response to the H7N9 virus and identify potential correlations between the anti-viral response and clinical outcomes in infected patients. METHODS: T lymphocyte subgroups, /chemokine levels in peripheral blood and H7N9 viral loads in the sputum were measured for 53 H7N9 patients (14 lethal and 39 non-lethal cases). 22 H1N1 patients and 15 healthy volunteers were selected as controls. RESULTS: Low proportions of T cells were observed in H7N9-infected individuals, particularly those who later died, and these correlated with clinical APACHE II scores and H7N9 virus loads in sputum. T-cell levels fluctuated during hospitalization and decreased suddenly on the day of death in those who succumbed to infection, whereas a dramatic increase in lymphocyte subgroups was observed in those who survived beyond the early stage of infection, with the levels of most lymphocyte subgroups significantly higher during the recovery phase compared to the early phase of infection. A cytokine/chemokine storm was also confirmed in this study. CONCLUSIONS: H7N9-infected individuals have low proportions of peripheral blood T lymphocyte subgroups, particularly those suffering fatal infections. The numbers of CD3+ T cells (including CD4+ and CD8+ T cells) may predict the clinical outcome of human H7N9 infection.
Persistent Identifierhttp://hdl.handle.net/10722/203183
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorTian, Len_US
dc.contributor.authorZheng, Sen_US
dc.contributor.authorYang, Sen_US
dc.contributor.authorDong, Yen_US
dc.contributor.authorWang, Yen_US
dc.contributor.authorCui, Den_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorLiang, Wen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorLi, Len_US
dc.date.accessioned2014-09-19T12:56:51Z-
dc.date.available2014-09-19T12:56:51Z-
dc.date.issued2014en_US
dc.identifier.citationJ Infect, 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/203183-
dc.description.abstractTcytokineo investigate peripheral blood lymphocyte subgroups response to the H7N9 virus and identify potential correlations between the anti-viral response and clinical outcomes in infected patients. METHODS: T lymphocyte subgroups, /chemokine levels in peripheral blood and H7N9 viral loads in the sputum were measured for 53 H7N9 patients (14 lethal and 39 non-lethal cases). 22 H1N1 patients and 15 healthy volunteers were selected as controls. RESULTS: Low proportions of T cells were observed in H7N9-infected individuals, particularly those who later died, and these correlated with clinical APACHE II scores and H7N9 virus loads in sputum. T-cell levels fluctuated during hospitalization and decreased suddenly on the day of death in those who succumbed to infection, whereas a dramatic increase in lymphocyte subgroups was observed in those who survived beyond the early stage of infection, with the levels of most lymphocyte subgroups significantly higher during the recovery phase compared to the early phase of infection. A cytokine/chemokine storm was also confirmed in this study. CONCLUSIONS: H7N9-infected individuals have low proportions of peripheral blood T lymphocyte subgroups, particularly those suffering fatal infections. The numbers of CD3+ T cells (including CD4+ and CD8+ T cells) may predict the clinical outcome of human H7N9 infection.en_US
dc.languageengen_US
dc.relation.ispartofJ Infecten_US
dc.titleDynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infectionen_US
dc.typeArticleen_US
dc.identifier.emailChen, H: hlchen@hku.hken_US
dc.identifier.authorityChen, H=rp00383en_US
dc.identifier.doi10.1016/j.jinf.2014.05.006en_US
dc.identifier.pmid24841136-
dc.identifier.hkuros238743en_US
dc.identifier.isiWOS:000341988900006-

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