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Article: Combined Paclitaxel-Eluting Balloon and Genous Cobalt-Chromium Alloy Stent Utilization in De Novo Coronary Stenoses (PEGASUS).

TitleCombined Paclitaxel-Eluting Balloon and Genous Cobalt-Chromium Alloy Stent Utilization in De Novo Coronary Stenoses (PEGASUS).
Authors
Issue Date2013
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1540-8183
Citation
Journal of Interventional Cardiology, 2013, v. 26 n. 6, p. 556-560 How to Cite?
AbstractOBJECTIVES: The aim of this study was to examine the angiographic result and its outcome predictors using the combination of paclitaxel-eluting balloon (PEB) and Genous stent. BACKGROUND: This approach to treat coronary stenoses is a logical strategy to strike a balance between minimizing restenosis and stent thrombosis. METHODS: From November 2010 to June 2012, 40 symptomatic patients with 44 de novo coronary lesions of diameter stenosis >/= 50% were treated with the combination of PEB and Genous stents. Angiographic and clinical follow-up were intended at 6 and 9 months, respectively. RESULTS: The mean age of patients was 61 +/- 11 years, with male predominance (83%). Diabetes mellitus and end-stage renal failure on peritoneal dialysis were found in 15 (38%) and 10 (25%) patients, respectively. Patients received dual antiplatelet therapy for 5.1 +/- 1.5 months post procedure. The size and length of PEB used was larger than the stents (3.13 +/- 0.46 mm and 28 +/- 9 mm vs. 2.98 +/- 0.36 mm and 23 +/- 7 mm). Restudy angiography was performed on 41 (95%) lesions in 37 (93%) patients at 5.9 +/- 1.7 months. Angiographic restenosis was seen in 5 (12%) lesions, and significantly associated with diabetes mellitus and dialysis dependency; the late lumen loss was 0.38 +/- 0.37 mm. At 9-month follow-up, no stent thrombosis was observed. CONCLUSIONS: The use of PEB combined with Genous stent is associated with a reasonably low restenosis and late lumen loss, whereas diabetes mellitus and renal failure with dialysis are poor predictors of angiographic restenosis.
Persistent Identifierhttp://hdl.handle.net/10722/203168
ISSN
2015 Impact Factor: 1.327
2015 SCImago Journal Rankings: 0.787
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJim, MH-
dc.contributor.authorFung, RCY-
dc.contributor.authorYiu, KH-
dc.contributor.authorNg, AKY-
dc.contributor.authorSiu, DCW-
dc.contributor.authorFan, KYY-
dc.date.accessioned2014-09-19T11:34:08Z-
dc.date.available2014-09-19T11:34:08Z-
dc.date.issued2013-
dc.identifier.citationJournal of Interventional Cardiology, 2013, v. 26 n. 6, p. 556-560-
dc.identifier.issn0896-4327-
dc.identifier.urihttp://hdl.handle.net/10722/203168-
dc.description.abstractOBJECTIVES: The aim of this study was to examine the angiographic result and its outcome predictors using the combination of paclitaxel-eluting balloon (PEB) and Genous stent. BACKGROUND: This approach to treat coronary stenoses is a logical strategy to strike a balance between minimizing restenosis and stent thrombosis. METHODS: From November 2010 to June 2012, 40 symptomatic patients with 44 de novo coronary lesions of diameter stenosis >/= 50% were treated with the combination of PEB and Genous stents. Angiographic and clinical follow-up were intended at 6 and 9 months, respectively. RESULTS: The mean age of patients was 61 +/- 11 years, with male predominance (83%). Diabetes mellitus and end-stage renal failure on peritoneal dialysis were found in 15 (38%) and 10 (25%) patients, respectively. Patients received dual antiplatelet therapy for 5.1 +/- 1.5 months post procedure. The size and length of PEB used was larger than the stents (3.13 +/- 0.46 mm and 28 +/- 9 mm vs. 2.98 +/- 0.36 mm and 23 +/- 7 mm). Restudy angiography was performed on 41 (95%) lesions in 37 (93%) patients at 5.9 +/- 1.7 months. Angiographic restenosis was seen in 5 (12%) lesions, and significantly associated with diabetes mellitus and dialysis dependency; the late lumen loss was 0.38 +/- 0.37 mm. At 9-month follow-up, no stent thrombosis was observed. CONCLUSIONS: The use of PEB combined with Genous stent is associated with a reasonably low restenosis and late lumen loss, whereas diabetes mellitus and renal failure with dialysis are poor predictors of angiographic restenosis.-
dc.languageeng-
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1540-8183-
dc.relation.ispartofJournal of Interventional Cardiology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleCombined Paclitaxel-Eluting Balloon and Genous Cobalt-Chromium Alloy Stent Utilization in De Novo Coronary Stenoses (PEGASUS).-
dc.typeArticle-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authoritySiu, DCW=rp00534-
dc.identifier.doi10.1111/joic.12072-
dc.identifier.pmid24118226-
dc.identifier.scopuseid_2-s2.0-84890129866-
dc.identifier.hkuros240228-
dc.identifier.volume26-
dc.identifier.issue6-
dc.identifier.spage556-
dc.identifier.epage560-
dc.identifier.isiWOS:000327998500003-
dc.publisher.placeUnited States-

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