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Article: Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis

TitleAntiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis
Authors
Issue Date2014
PublisherWiley for Cochrane Collaboration. The Journal's web site is located at http://www.wiley.com/WileyCDA/Brand/id-6.html?category=For+Working
Citation
Cochrane Database of Systematic Reviews, 2014, n. 8, p. article no. CD005501:1-16 How to Cite?
AbstractBACKGROUND: Intracranial venous thrombosis (ICVT) commonly presents with seizures in the acute period, and some people may develop recurrent seizures in the long term. The prophylactic use of antiepileptic drugs (AEDs) for the management of post-ICVT seizures is controversial, and there is currently no consensus on the optimal management of post-ICVT seizures. This is an updated version of the original Cochrane review published in The Cochrane Library 2006, Issue 3. OBJECTIVES: To assess the effects of AEDs for the primary and secondary prevention of seizures related to ICVT.(1) For the question of primary prevention, we aimed to examine whether AEDs reduce the likelihood of seizures in people who have had an ICVT but have not had a seizure.(2) For the question of secondary prevention, we aimed to examine whether AEDs reduce the likelihood of further seizures in people who have had an ICVT and at least one seizure. SEARCH METHODS: We aimed to identify relevant studies in the Cochrane Epilepsy Group and Cochrane Stroke Group Specialised Registers. We also undertook specialised searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2013, Issue 7) and MEDLINE (Ovid 1946 to 22 August 2013) and checked the reference lists of articles retrieved from the searches. SELECTION CRITERIA: We considered all randomised and quasi-randomised controlled trials in which participants were assigned to a treatment group (that is, receiving at least one AED) or control group (receiving placebo or no drug). DATA COLLECTION AND ANALYSIS: Both review authors independently screened and assessed the methodological quality of the studies. If studies had been included in the review, then one review author would have extracted the data and the other would have checked the extracted data. MAIN RESULTS: No relevant studies were found. AUTHORS' CONCLUSIONS: There is no evidence to support or refute the use of antiepileptic drugs for the primary or secondary prevention of seizures related to intracranial venous thrombosis. Well-designed randomised controlled trials are urgently needed to inform practice. Since the last version of this review no new studies have been found.
Persistent Identifierhttp://hdl.handle.net/10722/203121
ISSN
2014 Impact Factor: 6.035
2015 SCImago Journal Rankings: 2.366

 

DC FieldValueLanguage
dc.contributor.authorPrice, M-
dc.contributor.authorGünther, A-
dc.contributor.authorKwan, SKJ-
dc.date.accessioned2014-09-19T11:31:47Z-
dc.date.available2014-09-19T11:31:47Z-
dc.date.issued2014-
dc.identifier.citationCochrane Database of Systematic Reviews, 2014, n. 8, p. article no. CD005501:1-16-
dc.identifier.issn1469-493X-
dc.identifier.urihttp://hdl.handle.net/10722/203121-
dc.description.abstractBACKGROUND: Intracranial venous thrombosis (ICVT) commonly presents with seizures in the acute period, and some people may develop recurrent seizures in the long term. The prophylactic use of antiepileptic drugs (AEDs) for the management of post-ICVT seizures is controversial, and there is currently no consensus on the optimal management of post-ICVT seizures. This is an updated version of the original Cochrane review published in The Cochrane Library 2006, Issue 3. OBJECTIVES: To assess the effects of AEDs for the primary and secondary prevention of seizures related to ICVT.(1) For the question of primary prevention, we aimed to examine whether AEDs reduce the likelihood of seizures in people who have had an ICVT but have not had a seizure.(2) For the question of secondary prevention, we aimed to examine whether AEDs reduce the likelihood of further seizures in people who have had an ICVT and at least one seizure. SEARCH METHODS: We aimed to identify relevant studies in the Cochrane Epilepsy Group and Cochrane Stroke Group Specialised Registers. We also undertook specialised searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2013, Issue 7) and MEDLINE (Ovid 1946 to 22 August 2013) and checked the reference lists of articles retrieved from the searches. SELECTION CRITERIA: We considered all randomised and quasi-randomised controlled trials in which participants were assigned to a treatment group (that is, receiving at least one AED) or control group (receiving placebo or no drug). DATA COLLECTION AND ANALYSIS: Both review authors independently screened and assessed the methodological quality of the studies. If studies had been included in the review, then one review author would have extracted the data and the other would have checked the extracted data. MAIN RESULTS: No relevant studies were found. AUTHORS' CONCLUSIONS: There is no evidence to support or refute the use of antiepileptic drugs for the primary or secondary prevention of seizures related to intracranial venous thrombosis. Well-designed randomised controlled trials are urgently needed to inform practice. Since the last version of this review no new studies have been found.-
dc.languageeng-
dc.publisherWiley for Cochrane Collaboration. The Journal's web site is located at http://www.wiley.com/WileyCDA/Brand/id-6.html?category=For+Working-
dc.relation.ispartofCochrane Database of Systematic Reviews-
dc.rights‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2014, Issue 8. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Reference to the Review and hyperlink to the original version: Michelle Price, Albrecht Günther, Joseph SK Kwan. Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis. Cochrane Database of Systematic Reviews 2014, Issue 8. Art. No.: CD005501. DOI: 10.1002/14651858.CD005501.pub3 Persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD005501.pub3 (The most recent issue of the Cochrane Database of Systematic Reviews in which the Review published: The current version is shown in above persistent link to the article)-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAntiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis-
dc.typeArticle-
dc.identifier.emailKwan, SKJ: jskkwan@hku.hk-
dc.identifier.authorityKwan, SKJ=rp01868-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/14651858.CD005501.pub3-
dc.identifier.pmid25086250-
dc.identifier.hkuros238968-
dc.identifier.issue8-
dc.identifier.spagearticle no. CD005501:1-
dc.identifier.epage16-
dc.publisher.placeUnited Kingdom-

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