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Article: Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?

TitleMultipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?
Authors
Issue Date2013
Citation
Stem Cell Research and Therapy, 2013, v. 4, n. 6, article no. 151 How to Cite?
AbstractHeart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the permanent loss of cardiomyocytes after the insult, which contributes to progressive pathological left ventricular remodeling and progressive heart failure. As a result, cell-based therapies using multipotent (adult) stem cells and pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells) have been explored as potential therapeutic approaches to restore cardiac function in heart failure. Nevertheless, the optimal cell type with the best therapeutic efficacy and safety for heart regeneration is still unknown. In this review, the potential pros and cons of different types of multipotent (adult) stem cells and pluripotent stem cells that have been investigated in preclinical and clinical studies are reviewed, and the future perspective of stem cell-based therapy for heart regeneration is discussed. © 2013 BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/203078
ISSN
2015 Impact Factor: 4.504
2015 SCImago Journal Rankings: 1.405

 

DC FieldValueLanguage
dc.contributor.authorLiao, Sen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2014-09-19T11:29:42Z-
dc.date.available2014-09-19T11:29:42Z-
dc.date.issued2013en_US
dc.identifier.citationStem Cell Research and Therapy, 2013, v. 4, n. 6, article no. 151en_US
dc.identifier.issn1757-6512-
dc.identifier.urihttp://hdl.handle.net/10722/203078-
dc.description.abstractHeart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the permanent loss of cardiomyocytes after the insult, which contributes to progressive pathological left ventricular remodeling and progressive heart failure. As a result, cell-based therapies using multipotent (adult) stem cells and pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells) have been explored as potential therapeutic approaches to restore cardiac function in heart failure. Nevertheless, the optimal cell type with the best therapeutic efficacy and safety for heart regeneration is still unknown. In this review, the potential pros and cons of different types of multipotent (adult) stem cells and pluripotent stem cells that have been investigated in preclinical and clinical studies are reviewed, and the future perspective of stem cell-based therapy for heart regeneration is discussed. © 2013 BioMed Central Ltd.-
dc.languageengen_US
dc.relation.ispartofStem Cell Research and Therapyen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMultipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?en_US
dc.typeArticleen_US
dc.identifier.emailLiao, S: lsy923@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/scrt381-
dc.identifier.pmid24476362-
dc.identifier.scopuseid_2-s2.0-84891476149-
dc.identifier.hkuros236731en_US
dc.identifier.volume4en_US
dc.identifier.issue6en_US
dc.identifier.spagearticle no. 151en_US
dc.identifier.epagearticle no. 151en_US

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