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Article: Specific role of impaired glucose metabolism and diabetes mellitus in endothelial progenitor cell characteristics and function

TitleSpecific role of impaired glucose metabolism and diabetes mellitus in endothelial progenitor cell characteristics and function
Authors
Issue Date2014
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642
Citation
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, v. 34 n. 6, p. 1136-1143 How to Cite?
AbstractThe disease burden of diabetes mellitus (DM) and its associated cardiovascular complications represent a growing and major global health problem. Recent studies suggest that circulating exogenous endothelial progenitor cells (EPCs) play an important role in endothelial repair and neovascularization at sites of injury or ischemia. Both experimental and clinical studies have demonstrated that hyperglycemia related to DM can induce alterations to EPCs. The reduction and dysfunction of EPCs related to DM correlate with the occurrence and severity of microvascular and macrovascular complications, suggesting a close mechanistic link between EPC dysfunction and impaired vascular function/repair in DM. These alterations to EPCs, likely mediated by multiple pathophysiological mechanisms, including inflammation, oxidative stress, and alterations in Akt and the nitric oxide pathway, affect EPCs at multiple stages: differentiation and mobilization in the bone marrow, trafficking and survival in the circulation, and homing and neovascularization. Several different therapeutic approaches have consequently been proposed to reverse the reduction and dysfunction of EPCs in DM and may represent a novel therapeutic approach to prevent and treat DM-related cardiovascular complications. © 2014 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/203070
ISSN
2015 Impact Factor: 5.969
2015 SCImago Journal Rankings: 3.356
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYiu, KH-
dc.contributor.authorTse, HF-
dc.date.accessioned2014-09-19T11:29:25Z-
dc.date.available2014-09-19T11:29:25Z-
dc.date.issued2014-
dc.identifier.citationArteriosclerosis, Thrombosis, and Vascular Biology, 2014, v. 34 n. 6, p. 1136-1143-
dc.identifier.issn1079-5642-
dc.identifier.urihttp://hdl.handle.net/10722/203070-
dc.description.abstractThe disease burden of diabetes mellitus (DM) and its associated cardiovascular complications represent a growing and major global health problem. Recent studies suggest that circulating exogenous endothelial progenitor cells (EPCs) play an important role in endothelial repair and neovascularization at sites of injury or ischemia. Both experimental and clinical studies have demonstrated that hyperglycemia related to DM can induce alterations to EPCs. The reduction and dysfunction of EPCs related to DM correlate with the occurrence and severity of microvascular and macrovascular complications, suggesting a close mechanistic link between EPC dysfunction and impaired vascular function/repair in DM. These alterations to EPCs, likely mediated by multiple pathophysiological mechanisms, including inflammation, oxidative stress, and alterations in Akt and the nitric oxide pathway, affect EPCs at multiple stages: differentiation and mobilization in the bone marrow, trafficking and survival in the circulation, and homing and neovascularization. Several different therapeutic approaches have consequently been proposed to reverse the reduction and dysfunction of EPCs in DM and may represent a novel therapeutic approach to prevent and treat DM-related cardiovascular complications. © 2014 American Heart Association, Inc.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642-
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biology-
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.titleSpecific role of impaired glucose metabolism and diabetes mellitus in endothelial progenitor cell characteristics and function-
dc.typeArticle-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.doi10.1161/ATVBAHA.114.302192-
dc.identifier.pmid24743430-
dc.identifier.scopuseid_2-s2.0-84901495147-
dc.identifier.hkuros235711-
dc.identifier.volume34-
dc.identifier.issue6-
dc.identifier.spage1136-
dc.identifier.epage1143-
dc.identifier.isiWOS:000335809900009-
dc.publisher.placeUnited States-

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