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Article: Volumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport

TitleVolumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport
Authors
Issue Date2014
PublisherAmerican Physical Society. The Journal's web site is located at http://prl.aps.org
Citation
Physical Review Letters, 2014, v. 113 n. 11, article no. 118101, p. 118101:1-5 How to Cite?
AbstractIn this work, we developed a method that allows precise control over changes in the size of a cell via hydrostatic pressure changes in the medium. Specifically, we show that a sudden increase, or reduction, in the surrounding pressure, in the physiologically relevant range, triggers cross-membrane fluxes of sodium and potassium ions in leukemia cell lines K562 and HL60, resulting in reversible volumetric deformation with a characteristic time of around 30 min. Interestingly, healthy leukocytes do not respond to pressure shocks, suggesting that the cancer cells may have evolved the ability to adapt to pressure changes in their microenvironment. A model is also proposed to explain the observed cell deformation, which highlights how the apparent viscoelastic response of cells is governed by the microscopic cross-membrane transport.
Persistent Identifierhttp://hdl.handle.net/10722/203036
ISSN
2015 Impact Factor: 7.645
2015 SCImago Journal Rankings: 3.731

 

DC FieldValueLanguage
dc.contributor.authorHui, TH-
dc.contributor.authorZhou, ZL-
dc.contributor.authorQian, J-
dc.contributor.authorLin, Y-
dc.contributor.authorNgan, AHW-
dc.contributor.authorGao, H-
dc.date.accessioned2014-09-19T11:08:13Z-
dc.date.available2014-09-19T11:08:13Z-
dc.date.issued2014-
dc.identifier.citationPhysical Review Letters, 2014, v. 113 n. 11, article no. 118101, p. 118101:1-5-
dc.identifier.issn0031-9007-
dc.identifier.urihttp://hdl.handle.net/10722/203036-
dc.description.abstractIn this work, we developed a method that allows precise control over changes in the size of a cell via hydrostatic pressure changes in the medium. Specifically, we show that a sudden increase, or reduction, in the surrounding pressure, in the physiologically relevant range, triggers cross-membrane fluxes of sodium and potassium ions in leukemia cell lines K562 and HL60, resulting in reversible volumetric deformation with a characteristic time of around 30 min. Interestingly, healthy leukocytes do not respond to pressure shocks, suggesting that the cancer cells may have evolved the ability to adapt to pressure changes in their microenvironment. A model is also proposed to explain the observed cell deformation, which highlights how the apparent viscoelastic response of cells is governed by the microscopic cross-membrane transport.-
dc.languageeng-
dc.publisherAmerican Physical Society. The Journal's web site is located at http://prl.aps.org-
dc.relation.ispartofPhysical Review Letters-
dc.rightsPhysical Review Letters. Copyright © American Physical Society.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleVolumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport-
dc.typeArticle-
dc.identifier.emailLin, Y: ylin@hku.hk-
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hk-
dc.identifier.authorityLin, Y=rp00080en_US
dc.identifier.authorityNgan, AHW=rp00225en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1103/PhysRevLett.113.118101-
dc.identifier.hkuros239622-
dc.identifier.volume113-
dc.identifier.issue11-
dc.identifier.spage118101:1-
dc.identifier.epage118101:5-
dc.publisher.placeUnited States-

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