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Article: Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion

TitlePodoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion
Authors
Issue Date2014
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/mmr/
Citation
Molecular Medicine Reports, 2014, v. 10 n. 3, p. 1513-1518 How to Cite?
AbstractPodoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had contradictory results. In the present study, it was hypothesized that the different locations of PDPNpositive cells may explain these varying results. The present study aimed to focus on PDPN expression at the edge of esophageal cancer cell nests. In order to analyze the clinical significance of this PDPN expression, immunohistochemistry was performed using esophageal cancer tissue microarrays. PDPN expression at the edge of the cancer cell nest was found to be significantly associated with invasion (P<0.05) and poor prognosis (P<0.001) in patients with cancer. To further investigate the role of PDPN expression in cancer cells, the PDPN gene was cloned and transfected into esophageal squamous cell carcinoma (ESCC) cell lines. PDPN expression was also knocked down using small interfering RNA. PDPNpositive cancer cells were found to exhibit invasion characteristics. Thus, PDPN expression at the edge of a cancer cell nest may indicate invasion and represent a poor prognostic factor for ESCCs.
Persistent Identifierhttp://hdl.handle.net/10722/202746
ISSN
2015 Impact Factor: 1.559
2015 SCImago Journal Rankings: 0.637
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, JC-
dc.contributor.authorLi, Y-
dc.contributor.authorAi, JY-
dc.contributor.authorChen, K-
dc.contributor.authorZhu, YH-
dc.contributor.authorFu, L-
dc.contributor.authorQin, YR-
dc.contributor.authorWang, LJ-
dc.contributor.authorGuan, X-
dc.date.accessioned2014-09-19T09:33:34Z-
dc.date.available2014-09-19T09:33:34Z-
dc.date.issued2014-
dc.identifier.citationMolecular Medicine Reports, 2014, v. 10 n. 3, p. 1513-1518-
dc.identifier.issn1791-2997-
dc.identifier.urihttp://hdl.handle.net/10722/202746-
dc.description.abstractPodoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had contradictory results. In the present study, it was hypothesized that the different locations of PDPNpositive cells may explain these varying results. The present study aimed to focus on PDPN expression at the edge of esophageal cancer cell nests. In order to analyze the clinical significance of this PDPN expression, immunohistochemistry was performed using esophageal cancer tissue microarrays. PDPN expression at the edge of the cancer cell nest was found to be significantly associated with invasion (P<0.05) and poor prognosis (P<0.001) in patients with cancer. To further investigate the role of PDPN expression in cancer cells, the PDPN gene was cloned and transfected into esophageal squamous cell carcinoma (ESCC) cell lines. PDPN expression was also knocked down using small interfering RNA. PDPNpositive cancer cells were found to exhibit invasion characteristics. Thus, PDPN expression at the edge of a cancer cell nest may indicate invasion and represent a poor prognostic factor for ESCCs.-
dc.languageeng-
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/mmr/-
dc.relation.ispartofMolecular Medicine Reports-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePodoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion-
dc.typeArticle-
dc.identifier.emailFu, L: gracefu@graduate.hku.hk-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityFu, L=rp01435-
dc.identifier.authorityGuan, X=rp00454-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3892/mmr.2014.2338-
dc.identifier.pmid24938315-
dc.identifier.scopuseid_2-s2.0-84905440760-
dc.identifier.hkuros239744-
dc.identifier.volume10-
dc.identifier.issue3-
dc.identifier.spage1513-
dc.identifier.epage1518-
dc.identifier.isiWOS:000340854500050-
dc.publisher.placeGreece-

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