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Article: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

TitleKinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1
Authors
Issue Date2013
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2013, v. 49 n. 80, p. 9134-9136 How to Cite?
AbstractThe N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (logK = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter. © 2013 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/202606
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDu, X-
dc.contributor.authorLi, H-
dc.contributor.authorWang, X-
dc.contributor.authorLiu, Q-
dc.contributor.authorNi, J-
dc.contributor.authorSun, H-
dc.date.accessioned2014-09-19T08:42:28Z-
dc.date.available2014-09-19T08:42:28Z-
dc.date.issued2013-
dc.identifier.citationChemical Communications, 2013, v. 49 n. 80, p. 9134-9136-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/202606-
dc.description.abstractThe N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (logK = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter. © 2013 The Royal Society of Chemistry.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp-
dc.relation.ispartofChemical Communications-
dc.titleKinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1-
dc.typeArticle-
dc.identifier.emailDu, X: xbdu@hku.hk-
dc.identifier.emailLi, H: hylichem@hku.hk-
dc.identifier.emailWang, X: wmouse@hku.hk-
dc.identifier.emailSun, H: hsun@hku.hk-
dc.identifier.authoritySun, H=rp00777-
dc.identifier.doi10.1039/c3cc45360j-
dc.identifier.pmid23962988-
dc.identifier.scopuseid_2-s2.0-84884193708-
dc.identifier.hkuros239330-
dc.identifier.volume49-
dc.identifier.issue80-
dc.identifier.spage9134-
dc.identifier.epage9136-
dc.identifier.isiWOS:000324490200018-
dc.publisher.placeUnited Kingdom-

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