File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1378/chest.13-1651
- Scopus: eid_2-s2.0-84897447675
- PMID: 24337193
- WOS: WOS:000337355600016
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Surfactant protein B gene polymorphism is associated with severe influenza.
Title | Surfactant protein B gene polymorphism is associated with severe influenza. |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org |
Citation | Chest, 2014, v. 145 n. 6, p. 1237-1243 How to Cite? |
Abstract | Background: Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza. Methods: In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) infection who were matched for age, sex, and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with those of the general Han Chinese population. Results: This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, an SNP in the surfactant protein B gene(SFTPB ), was significantly asso ciated with severe disease (OR = 3.37, P = .0048), although the P value was .057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed in the univariate analysis to be associated with severe disease. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR = 2.087, P = .023). Compared to the general Han Chinese population, the C/C genotype was overrepresented in patients with severe A(H1N1)pdm09 infection (OR = 3.232, P = .00000056). Conclusions: SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies. © 2014 American College of Chest Physicians. |
Persistent Identifier | http://hdl.handle.net/10722/202521 |
ISSN | 2023 Impact Factor: 9.5 2023 SCImago Journal Rankings: 2.123 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | To, KKW | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Song, YQ | - |
dc.contributor.author | Hung, IFN | - |
dc.contributor.author | Ip, WCT | - |
dc.contributor.author | Cheng, ZS | - |
dc.contributor.author | Chan, ASF | - |
dc.contributor.author | Kao, RYT | - |
dc.contributor.author | Wu, AKL | - |
dc.contributor.author | Chau, SS | - |
dc.contributor.author | Luk, WK | - |
dc.contributor.author | Ip, MSM | - |
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2014-09-19T08:25:13Z | - |
dc.date.available | 2014-09-19T08:25:13Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Chest, 2014, v. 145 n. 6, p. 1237-1243 | - |
dc.identifier.issn | 0012-3692 | - |
dc.identifier.uri | http://hdl.handle.net/10722/202521 | - |
dc.description.abstract | Background: Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza. Methods: In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) infection who were matched for age, sex, and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with those of the general Han Chinese population. Results: This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, an SNP in the surfactant protein B gene(SFTPB ), was significantly asso ciated with severe disease (OR = 3.37, P = .0048), although the P value was .057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed in the univariate analysis to be associated with severe disease. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR = 2.087, P = .023). Compared to the general Han Chinese population, the C/C genotype was overrepresented in patients with severe A(H1N1)pdm09 infection (OR = 3.232, P = .00000056). Conclusions: SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies. © 2014 American College of Chest Physicians. | - |
dc.language | eng | - |
dc.publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org | - |
dc.relation.ispartof | Chest | - |
dc.title | Surfactant protein B gene polymorphism is associated with severe influenza. | - |
dc.type | Article | - |
dc.identifier.email | To, KKW: kelvinto@hkucc.hku.hk | - |
dc.identifier.email | Zhou, J: jiezhou@hku.hk | - |
dc.identifier.email | Song, YQ: songy@hku.hk | - |
dc.identifier.email | Hung, IFN: ivanhung@hkucc.hku.hk | - |
dc.identifier.email | Ip, WCT: whitneyi@hku.hk | - |
dc.identifier.email | Cheng, ZS: chzhshan@hku.hk | - |
dc.identifier.email | Chan, ASF: sfchanaa@hku.hk | - |
dc.identifier.email | Kao, RYT: rytkao@hkucc.hku.hk | - |
dc.identifier.email | Wu, AKL: alanklwu@hkucc.hku.hk | - |
dc.identifier.email | Ip, MSM: msmip@hku.hk | - |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | To, KKW=rp01384 | - |
dc.identifier.authority | Zhou, J=rp01412 | - |
dc.identifier.authority | Song, YQ=rp00488 | - |
dc.identifier.authority | Hung, IFN=rp00508 | - |
dc.identifier.authority | Kao, RYT=rp00481 | - |
dc.identifier.authority | Ip, MSM=rp00347 | - |
dc.identifier.authority | Chan, KH=rp01921 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.identifier.doi | 10.1378/chest.13-1651 | - |
dc.identifier.pmid | 24337193 | - |
dc.identifier.scopus | eid_2-s2.0-84897447675 | - |
dc.identifier.hkuros | 238374 | - |
dc.identifier.volume | 145 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1237 | - |
dc.identifier.epage | 1243 | - |
dc.identifier.isi | WOS:000337355600016 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0012-3692 | - |