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Article: Surfactant protein B gene polymorphism is associated with severe influenza.

TitleSurfactant protein B gene polymorphism is associated with severe influenza.
Authors
Issue Date2014
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2014, v. 145 n. 6, p. 1237-1243 How to Cite?
AbstractBackground: Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza. Methods: In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) infection who were matched for age, sex, and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with those of the general Han Chinese population. Results: This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, an SNP in the surfactant protein B gene(SFTPB ), was significantly asso ciated with severe disease (OR = 3.37, P = .0048), although the P value was .057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed in the univariate analysis to be associated with severe disease. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR = 2.087, P = .023). Compared to the general Han Chinese population, the C/C genotype was overrepresented in patients with severe A(H1N1)pdm09 infection (OR = 3.232, P = .00000056). Conclusions: SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies. © 2014 American College of Chest Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/202521
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTo, KKW-
dc.contributor.authorZhou, J-
dc.contributor.authorSong, YQ-
dc.contributor.authorHung, IFN-
dc.contributor.authorIp, WCT-
dc.contributor.authorCheng, ZS-
dc.contributor.authorChan, ASF-
dc.contributor.authorKao, RYT-
dc.contributor.authorWu, AKL-
dc.contributor.authorChau, SS-
dc.contributor.authorLuk, WK-
dc.contributor.authorIp, MSM-
dc.contributor.authorChan, KH-
dc.contributor.authorYuen, KY-
dc.date.accessioned2014-09-19T08:25:13Z-
dc.date.available2014-09-19T08:25:13Z-
dc.date.issued2014-
dc.identifier.citationChest, 2014, v. 145 n. 6, p. 1237-1243-
dc.identifier.issn0012-3692-
dc.identifier.urihttp://hdl.handle.net/10722/202521-
dc.description.abstractBackground: Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza. Methods: In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) infection who were matched for age, sex, and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with those of the general Han Chinese population. Results: This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, an SNP in the surfactant protein B gene(SFTPB ), was significantly asso ciated with severe disease (OR = 3.37, P = .0048), although the P value was .057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed in the univariate analysis to be associated with severe disease. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR = 2.087, P = .023). Compared to the general Han Chinese population, the C/C genotype was overrepresented in patients with severe A(H1N1)pdm09 infection (OR = 3.232, P = .00000056). Conclusions: SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies. © 2014 American College of Chest Physicians.-
dc.languageeng-
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org-
dc.relation.ispartofChest-
dc.titleSurfactant protein B gene polymorphism is associated with severe influenza.-
dc.typeArticle-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailZhou, J: jiezhou@hku.hk-
dc.identifier.emailSong, YQ: songy@hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailIp, WCT: whitneyi@hku.hk-
dc.identifier.emailCheng, ZS: chzhshan@hku.hk-
dc.identifier.emailChan, ASF: sfchanaa@hku.hk-
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hk-
dc.identifier.emailWu, AKL: alanklwu@hkucc.hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityZhou, J=rp01412-
dc.identifier.authoritySong, YQ=rp00488-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityKao, RYT=rp00481-
dc.identifier.authorityIp, MSM=rp00347-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.doi10.1378/chest.13-1651-
dc.identifier.pmid24337193-
dc.identifier.scopuseid_2-s2.0-84897447675-
dc.identifier.hkuros238374-
dc.identifier.volume145-
dc.identifier.issue6-
dc.identifier.spage1237-
dc.identifier.epage1243-
dc.identifier.isiWOS:000337355600016-
dc.publisher.placeUnited States-

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