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Article: Glass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries prevention - Results from a randomized clinical trial
Title | Glass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries prevention - Results from a randomized clinical trial |
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Authors | |
Keywords | Atraumatic restorative treatment Child Dental caries Dental fissures Fissure sealants Glass-ionomer cement Preventive dentistry |
Issue Date | 2014 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcoralhealth/ |
Citation | BMC Oral Health, 2014, v. 14, article no. 54 How to Cite? |
Abstract | Background: The relative performance of ART sealant and fluoride-releasing resin sealant in preventing fissure caries in permanent molars was compared in a randomized clinical trial conducted in southern China (ClinicalTrials.gov NCT01829334).
Methods: After obtaining ethical approval, healthy schoolchildren who had permanent first molars with occlusal fissures which were sound but deep or presented with only incipient caries were recruited for the study. Included molars were randomly allocated into one of four parallel study groups in units of left/right teeth per mouth. Two of the four groups adopted the methods of ART or fluoride-releasing resin sealant placement while the other two groups adopted the topical fluoride application methods. Fissure status of the molars in each group was evaluated every 6 months. Development of dentine caries and sealant retention over 24 months in the molars in the two sealant-using groups was compared in this report. Outcome on cost-effectiveness of all four groups over 36 months will be reported elsewhere.
Results: At baseline, a total of 280 children (383 molars) with mean age 7.8 years were involved for the two sealant groups. After 24 months, 261 children (357 molars) were followed. Proportions of molars with dentine caries were 7.3% and 3.9% in the ART sealant and fluoride-releasing resin sealant groups, respectively (chi-square test, p = 0.171). Life-table survival analysis showed that sealant retention (full and partial) rate over 24 months for the resin sealant (73%) was significantly higher than that (50%) for the ART sealant (p < 0.001). Molar survival (no development of dentine caries) rates in the ART sealant (93%) and fluoride-releasing resin sealant (96%) groups were not significantly different (p = 0.169). Multilevel logistic regression (GEE modeling) accounting for the effects of data clustering and confounding factors confirmed this finding.
Conclusions: Though the retention of fluoride-releasing resin sealant was better than that of the ART sealant, their effectiveness in preventing fissure caries in permanent molars did not differ significantly over 24 months. ART sealants could be a good alternative when and where resources for resin sealant placement are not readily available. |
Persistent Identifier | http://hdl.handle.net/10722/202474 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, B | en_US |
dc.contributor.author | Xiao, Y | en_US |
dc.contributor.author | Chu, CH | en_US |
dc.contributor.author | Lo, ECM | en_US |
dc.date.accessioned | 2014-09-19T07:50:44Z | - |
dc.date.available | 2014-09-19T07:50:44Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | BMC Oral Health, 2014, v. 14, article no. 54 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/202474 | - |
dc.description.abstract | Background: The relative performance of ART sealant and fluoride-releasing resin sealant in preventing fissure caries in permanent molars was compared in a randomized clinical trial conducted in southern China (ClinicalTrials.gov NCT01829334). Methods: After obtaining ethical approval, healthy schoolchildren who had permanent first molars with occlusal fissures which were sound but deep or presented with only incipient caries were recruited for the study. Included molars were randomly allocated into one of four parallel study groups in units of left/right teeth per mouth. Two of the four groups adopted the methods of ART or fluoride-releasing resin sealant placement while the other two groups adopted the topical fluoride application methods. Fissure status of the molars in each group was evaluated every 6 months. Development of dentine caries and sealant retention over 24 months in the molars in the two sealant-using groups was compared in this report. Outcome on cost-effectiveness of all four groups over 36 months will be reported elsewhere. Results: At baseline, a total of 280 children (383 molars) with mean age 7.8 years were involved for the two sealant groups. After 24 months, 261 children (357 molars) were followed. Proportions of molars with dentine caries were 7.3% and 3.9% in the ART sealant and fluoride-releasing resin sealant groups, respectively (chi-square test, p = 0.171). Life-table survival analysis showed that sealant retention (full and partial) rate over 24 months for the resin sealant (73%) was significantly higher than that (50%) for the ART sealant (p < 0.001). Molar survival (no development of dentine caries) rates in the ART sealant (93%) and fluoride-releasing resin sealant (96%) groups were not significantly different (p = 0.169). Multilevel logistic regression (GEE modeling) accounting for the effects of data clustering and confounding factors confirmed this finding. Conclusions: Though the retention of fluoride-releasing resin sealant was better than that of the ART sealant, their effectiveness in preventing fissure caries in permanent molars did not differ significantly over 24 months. ART sealants could be a good alternative when and where resources for resin sealant placement are not readily available. | - |
dc.language | eng | en_US |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcoralhealth/ | - |
dc.relation.ispartof | BMC Oral Health | en_US |
dc.rights | BMC Oral Health. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Atraumatic restorative treatment | - |
dc.subject | Child | - |
dc.subject | Dental caries | - |
dc.subject | Dental fissures | - |
dc.subject | Fissure sealants | - |
dc.subject | Glass-ionomer cement | - |
dc.subject | Preventive dentistry | - |
dc.title | Glass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries prevention - Results from a randomized clinical trial | en_US |
dc.type | Article | en_US |
dc.identifier.email | Liu, B: smilelby@hku.hk | en_US |
dc.identifier.email | Chu, CH: chchu@hku.hk | en_US |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | en_US |
dc.identifier.authority | Chu, CH=rp00022 | en_US |
dc.identifier.authority | Lo, ECM=rp00015 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/1472-6831-14-54 | en_US |
dc.identifier.pmid | 24886444 | - |
dc.identifier.pmcid | PMC4039987 | - |
dc.identifier.scopus | eid_2-s2.0-84901587348 | - |
dc.identifier.hkuros | 239717 | en_US |
dc.identifier.hkuros | 231302 | - |
dc.identifier.volume | 14 | en_US |
dc.identifier.spage | 54 | en_US |
dc.identifier.epage | 54 | en_US |
dc.identifier.eissn | 1472-6831 | - |
dc.identifier.isi | WOS:000336997600001 | - |
dc.identifier.issnl | 1472-6831 | - |