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Article: Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms

TitleNanoparticle-encapsulated chlorhexidine against oral bacterial biofilms
Authors
Issue Date2014
Citation
PLoS One, 2014, v. 9 n. 8, p. e103234 How to Cite?
AbstractBackground: Chlorhexidine (CHX) is a widely used antimicrobial agent in dentistry. Herein, we report the synthesis of a novel mesoporous silica nanoparticle-encapsulated pure CHX (Nano-CHX), and its mechanical profile and antimicrobial properties against oral biofilms. Methodology/Principal Findings: The release of CHX from the Nano-CHX was characterized by UV/visible absorption spectroscopy. The antimicrobial properties of Nano-CHX were evaluated in both planktonic and biofilm modes of representative oral pathogenic bacteria. The Nano-CHX demonstrated potent antibacterial effects on planktonic bacteria and mono-species biofilms at the concentrations of 50-200 mu g/mL against Streptococcus mutans, Streptococcus sobrinus, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Enterococccus faecalis. Moreover, Nano-CHX effectively suppressed multi-species biofilms such as S. mutans, F. nucleatum, A. actinomycetemcomitans and Porphyromonas gingivalis up to 72 h. Conclusions/Significance: This pioneering study demonstrates the potent antibacterial effects of the Nano-CHX on oral biofilms, and it may be developed as a novel and promising anti-biofilm agent for clinical use.
Persistent Identifierhttp://hdl.handle.net/10722/202463
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
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DC FieldValueLanguage
dc.contributor.authorSeneviratne, CJen_US
dc.contributor.authorLeung, CFKen_US
dc.contributor.authorWong, CHen_US
dc.contributor.authorLee, SFen_US
dc.contributor.authorLI, Xen_US
dc.contributor.authorLeung, PCen_US
dc.contributor.authorLau, CBSen_US
dc.contributor.authorWat, Een_US
dc.contributor.authorJin, Len_US
dc.date.accessioned2014-09-19T07:50:42Z-
dc.date.available2014-09-19T07:50:42Z-
dc.date.issued2014en_US
dc.identifier.citationPLoS One, 2014, v. 9 n. 8, p. e103234en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/202463-
dc.description.abstractBackground: Chlorhexidine (CHX) is a widely used antimicrobial agent in dentistry. Herein, we report the synthesis of a novel mesoporous silica nanoparticle-encapsulated pure CHX (Nano-CHX), and its mechanical profile and antimicrobial properties against oral biofilms. Methodology/Principal Findings: The release of CHX from the Nano-CHX was characterized by UV/visible absorption spectroscopy. The antimicrobial properties of Nano-CHX were evaluated in both planktonic and biofilm modes of representative oral pathogenic bacteria. The Nano-CHX demonstrated potent antibacterial effects on planktonic bacteria and mono-species biofilms at the concentrations of 50-200 mu g/mL against Streptococcus mutans, Streptococcus sobrinus, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Enterococccus faecalis. Moreover, Nano-CHX effectively suppressed multi-species biofilms such as S. mutans, F. nucleatum, A. actinomycetemcomitans and Porphyromonas gingivalis up to 72 h. Conclusions/Significance: This pioneering study demonstrates the potent antibacterial effects of the Nano-CHX on oral biofilms, and it may be developed as a novel and promising anti-biofilm agent for clinical use.-
dc.languageengen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNanoparticle-encapsulated chlorhexidine against oral bacterial biofilmsen_US
dc.typeArticleen_US
dc.identifier.emailSeneviratne, CJ: jaya@hku.hken_US
dc.identifier.emailLeung, CFK: kcfleung@hku.hken_US
dc.identifier.emailJin, L: ljjin@hkucc.hku.hken_US
dc.identifier.authoritySeneviratne, CJ=rp01372en_US
dc.identifier.authorityJin, L=rp00028en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0103234en_US
dc.identifier.pmid25170958-
dc.identifier.hkuros238231en_US
dc.identifier.volume9en_US
dc.identifier.spagee103234en_US
dc.identifier.epagee103234en_US
dc.identifier.isiWOS:000341127500010-
dc.relation.projectNano-encapsulated Chinese herbal extracts as novel immunomodulators and enhancers of innate host defense in human gingiva-
dc.relation.projectCrosstalk of human gingival/oral epithelial cells and monocytes with P. gingivalis/P. gingivalis DNA: Epigenetic regulation and molecular signaling-

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