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Conference Paper: Endothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged mice

TitleEndothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged mice
Authors
KeywordsBiology
Issue Date2014
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. 1 suppl., abstract no. LB655 How to Cite?
AbstractEndothelin-1 (ET-1) is a 21 amino acid vasoconstrictor and implicated in the regulation of hypertention. Recently, our colleagues found that transgenic mice (TET-1) with endothelial ET-1 over-expression developed hypertention in young mice by changing vascular properties. However, the effects of over-expressing endothelial ET-1 on cardiovascular system in aged mice are still unclear. Therefore, this study investigated the blood pressure and heart rate of TET-1 aged mice and non-transgenic (NTg) aged mice (1.5-2 years old). A non-invasive tail cuff measurement showed that a significant elevation of both systolic (115.1 ± 2.935 vs 103.5 ± 1.846 mmHg, p<0.01) and diastolic ...
DescriptionAbstract no. LB655
This journal suppl. is proceedings of EB 2014 Meeting
Open Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/202295
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLuo, X-
dc.contributor.authorXia, Z-
dc.contributor.authorChung, SK-
dc.contributor.authorCheung, CW-
dc.date.accessioned2014-09-04T07:15:41Z-
dc.date.available2014-09-04T07:15:41Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. 1 suppl., abstract no. LB655-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/202295-
dc.descriptionAbstract no. LB655-
dc.descriptionThis journal suppl. is proceedings of EB 2014 Meeting-
dc.descriptionOpen Access Journal-
dc.description.abstractEndothelin-1 (ET-1) is a 21 amino acid vasoconstrictor and implicated in the regulation of hypertention. Recently, our colleagues found that transgenic mice (TET-1) with endothelial ET-1 over-expression developed hypertention in young mice by changing vascular properties. However, the effects of over-expressing endothelial ET-1 on cardiovascular system in aged mice are still unclear. Therefore, this study investigated the blood pressure and heart rate of TET-1 aged mice and non-transgenic (NTg) aged mice (1.5-2 years old). A non-invasive tail cuff measurement showed that a significant elevation of both systolic (115.1 ± 2.935 vs 103.5 ± 1.846 mmHg, p<0.01) and diastolic ...-
dc.languageeng-
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journal-
dc.subjectBiology-
dc.titleEndothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged miceen_US
dc.typeConference_Paperen_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hk-
dc.identifier.emailChung, SK: skchung@hkucc.hku.hk-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros235868-
dc.identifier.volume28-
dc.identifier.issue1 suppl.-
dc.publisher.placeUnited States-

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