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Article: Application of microRNAs in diabetes mellitus

TitleApplication of microRNAs in diabetes mellitus
Authors
Issue Date2014
Citation
The Journal of endocrinology, 2014, v. 222 n. 1, p. R1-R10 How to Cite?
AbstractMicroRNAs (miRNAs) are small molecules negatively regulating gene expression by diminishing their target messenger RNAs. Emerging studies have shown that miRNAs play diverse roles in diabetes mellitus. Type 1 diabetes (T1D) and type 2 diabetes (T2D) are two major types of diabetes. T1D is characterized by the reduction of insulin release in pancreatic beta-cells while T2D is caused by islet beta-cell dysfunction in response to insulin resistance. The present study reviewed the miRNAs that controlled insulin release and production by regulating cellular membrane electrical excitability (ATP/ADP ratio), insulin granule exocytosis, insulin synthesis in beta-cell, and beta-cell fate and islet mass formation. We also reviewed miRNAs involved the insulin resistance of liver, fat and skeletal muscle, which changed insulin sensitivity pathways (insulin receptors, glucose transporter type 4, and protein kinase B pathways). This study discussed the potential application of miRNAs in diabetes, such as the use of gene therapy and therapeutic compounds to recover miRNA function in diabetes, as well as the role of miRNAs as potential biomarkers for T1D and T2D.
Persistent Identifierhttp://hdl.handle.net/10722/201642
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Hen_US
dc.contributor.authorLan, HYen_US
dc.contributor.authorRoukos, DHen_US
dc.contributor.authorCho, WCen_US
dc.date.accessioned2014-08-21T07:34:02Z-
dc.date.available2014-08-21T07:34:02Z-
dc.date.issued2014en_US
dc.identifier.citationThe Journal of endocrinology, 2014, v. 222 n. 1, p. R1-R10en_US
dc.identifier.urihttp://hdl.handle.net/10722/201642-
dc.description.abstractMicroRNAs (miRNAs) are small molecules negatively regulating gene expression by diminishing their target messenger RNAs. Emerging studies have shown that miRNAs play diverse roles in diabetes mellitus. Type 1 diabetes (T1D) and type 2 diabetes (T2D) are two major types of diabetes. T1D is characterized by the reduction of insulin release in pancreatic beta-cells while T2D is caused by islet beta-cell dysfunction in response to insulin resistance. The present study reviewed the miRNAs that controlled insulin release and production by regulating cellular membrane electrical excitability (ATP/ADP ratio), insulin granule exocytosis, insulin synthesis in beta-cell, and beta-cell fate and islet mass formation. We also reviewed miRNAs involved the insulin resistance of liver, fat and skeletal muscle, which changed insulin sensitivity pathways (insulin receptors, glucose transporter type 4, and protein kinase B pathways). This study discussed the potential application of miRNAs in diabetes, such as the use of gene therapy and therapeutic compounds to recover miRNA function in diabetes, as well as the role of miRNAs as potential biomarkers for T1D and T2D.en_US
dc.languageengen_US
dc.relation.ispartofThe Journal of endocrinologyen_US
dc.titleApplication of microRNAs in diabetes mellitusen_US
dc.typeArticleen_US
dc.identifier.emailChen, H: haiyong@hku.hken_US
dc.identifier.authorityChen, H=rp01923en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1530/JOE-13-0544en_US
dc.identifier.pmid24781254-
dc.identifier.hkuros232086en_US
dc.identifier.isiWOS:000339256800001-

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