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Conference Paper: Thymoquinone causes endothelium-dependent augmentation of contraction depending on activation of soluble guanylyl cyclase in isolated arteries

TitleThymoquinone causes endothelium-dependent augmentation of contraction depending on activation of soluble guanylyl cyclase in isolated arteries
Authors
Issue Date2013
Citation
The 11th International Symposium on Mechanisms of Vasodilatation (MOVD 2013), Zurich, Switzerland, 4-6 October 2013. How to Cite?
AbstractINTRODUCTION: Experiments were designed to determine the effects of thymoquinone, an alkaloid with in vivo vasodilator properties, in isolated arteries. METHODS: Rings, with or without endothelium, of rat mesenteric arteries, rat aorta and porcine coronary arteries were suspended in conventional organ chambers for isometric tension recording. Certain rings were incubated with inhibitors of nitric oxide (NO) synthase inhibitor (L-N^G-nitroarginine methyl ester, L-NAME) or soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, ODQ). They were contracted with phenylephrine (rat arteries) or prostaglandin F_2alpha (porcine coronary arteries) and exposed to increasing ...
DescriptionPoster - Vascular Responsiveness: no. 4/7
Persistent Identifierhttp://hdl.handle.net/10722/201274

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorDetremmerie, CMSen_US
dc.contributor.authorLi, Zen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorAlkharfy, Ken_US
dc.contributor.authorGao, Yen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2014-08-21T07:20:16Z-
dc.date.available2014-08-21T07:20:16Z-
dc.date.issued2013en_US
dc.identifier.citationThe 11th International Symposium on Mechanisms of Vasodilatation (MOVD 2013), Zurich, Switzerland, 4-6 October 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10722/201274-
dc.descriptionPoster - Vascular Responsiveness: no. 4/7-
dc.description.abstractINTRODUCTION: Experiments were designed to determine the effects of thymoquinone, an alkaloid with in vivo vasodilator properties, in isolated arteries. METHODS: Rings, with or without endothelium, of rat mesenteric arteries, rat aorta and porcine coronary arteries were suspended in conventional organ chambers for isometric tension recording. Certain rings were incubated with inhibitors of nitric oxide (NO) synthase inhibitor (L-N^G-nitroarginine methyl ester, L-NAME) or soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, ODQ). They were contracted with phenylephrine (rat arteries) or prostaglandin F_2alpha (porcine coronary arteries) and exposed to increasing ...-
dc.languageengen_US
dc.relation.ispartof11th MOVD International Symposium 2013en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThymoquinone causes endothelium-dependent augmentation of contraction depending on activation of soluble guanylyl cyclase in isolated arteriesen_US
dc.typeConference_Paperen_US
dc.identifier.emailLeung, SWS: swsleung@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturepostprint-
dc.identifier.hkuros233041en_US

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