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Article: Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder.

TitleSex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder.
Authors
Issue Date2014
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
BioMed Research International, 2014, v. 2014, article no. :673165, p. 1-9 How to Cite?
AbstractConduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls.
Persistent Identifierhttp://hdl.handle.net/10722/201117
ISSN
2015 Impact Factor: 2.134
2015 SCImago Journal Rankings: 0.725
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jen_US
dc.contributor.authorGao, Jen_US
dc.contributor.authorShi, Hen_US
dc.contributor.authorHuang, Ben_US
dc.contributor.authorSitu, Wen_US
dc.contributor.authorYi, Jen_US
dc.contributor.authorZhu, Zen_US
dc.contributor.authorYao, Sen_US
dc.date.accessioned2014-08-21T07:14:21Z-
dc.date.available2014-08-21T07:14:21Z-
dc.date.issued2014en_US
dc.identifier.citationBioMed Research International, 2014, v. 2014, article no. :673165, p. 1-9en_US
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/10722/201117-
dc.description.abstractConduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html-
dc.relation.ispartofBioMed Research Internationalen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder.en_US
dc.typeArticleen_US
dc.identifier.emailGao, J: galeng@hku.hken_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2014/673165-
dc.identifier.pmid24829912-
dc.identifier.pmcidPMC4009134-
dc.identifier.hkuros233235en_US
dc.identifier.volume2014, article no. :673165-
dc.identifier.spage1en_US
dc.identifier.epage9en_US
dc.identifier.isiWOS:000335049800001-
dc.publisher.placeUnited States-

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