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Article: The Impact Of Hypoxia In Hepatocellular Carcinoma Metastasis

TitleThe Impact Of Hypoxia In Hepatocellular Carcinoma Metastasis
Authors
Issue Date2014
Citation
Frontiers Of Medicine, 2014 How to Cite?
AbstractHypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondary growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/201058

 

DC FieldValueLanguage
dc.contributor.authorWong, CCLen_US
dc.contributor.authorKai, AKLen_US
dc.contributor.authorNg, IOLen_US
dc.date.accessioned2014-08-21T07:11:59Z-
dc.date.available2014-08-21T07:11:59Z-
dc.date.issued2014en_US
dc.identifier.citationFrontiers Of Medicine, 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/201058-
dc.description.abstractHypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondary growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.en_US
dc.languageengen_US
dc.relation.ispartofFrontiers Of Medicineen_US
dc.titleThe Impact Of Hypoxia In Hepatocellular Carcinoma Metastasisen_US
dc.typeArticleen_US
dc.identifier.emailWong, CCL: carmencl@pathology.hku.hken_US
dc.identifier.emailKai, AKL: klakai@hku.hken_US
dc.identifier.emailNg, IOL: iolng@hku.hken_US
dc.identifier.authorityWong, CCL=rp01602en_US
dc.identifier.hkuros233440en_US

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