File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1155/2014/126038
- Scopus: eid_2-s2.0-84929939903
- PMID: 25161999
- WOS: WOS:000340368100001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Interactions between E-cadherin and microRNA deregulation in head and neck cancers: The potential interplay
Title | Interactions between E-cadherin and microRNA deregulation in head and neck cancers: The potential interplay |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html |
Citation | Biomed Research International, 2014, v. 2014, article no. 126038 How to Cite? |
Abstract | E-cadherin expression in the head and neck epithelium is essential for the morphogenesis and homeostasis of epithelial tissues. The cadherin-mediated cell-cell contacts are required for the anchorage-dependent growth of epithelial cells. Further, survival and proliferation require physical tethering created by proper cell-cell adhesion. Otherwise, the squamous epithelial cells will undergo programmed cell death. Head and neck cancers can escape from anoikis and enter into the epithelial-mesenchymal transition stages via the modulation of E-cadherin expression with epigenetic mechanisms. At epigenetic level, gene expression control is not dependent on the DNA sequence. In the context of E-cadherin regulation in head and neck cancers, 2 major mechanisms including de novo promoter hypermethylation and microRNA dysregulation are most extensively studied. Both of them control E-cadherin expression at transcription level and subsequently hinder the overall E-cadherin protein level in the head and neck cancer cells. Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2. |
Persistent Identifier | http://hdl.handle.net/10722/200939 |
ISSN | 2021 Impact Factor: 3.246 2020 SCImago Journal Rankings: 0.772 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, TS | en_US |
dc.contributor.author | Gao, W | en_US |
dc.contributor.author | Chan, JYW | en_US |
dc.date.accessioned | 2014-08-21T07:07:39Z | - |
dc.date.available | 2014-08-21T07:07:39Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Biomed Research International, 2014, v. 2014, article no. 126038 | en_US |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200939 | - |
dc.description.abstract | E-cadherin expression in the head and neck epithelium is essential for the morphogenesis and homeostasis of epithelial tissues. The cadherin-mediated cell-cell contacts are required for the anchorage-dependent growth of epithelial cells. Further, survival and proliferation require physical tethering created by proper cell-cell adhesion. Otherwise, the squamous epithelial cells will undergo programmed cell death. Head and neck cancers can escape from anoikis and enter into the epithelial-mesenchymal transition stages via the modulation of E-cadherin expression with epigenetic mechanisms. At epigenetic level, gene expression control is not dependent on the DNA sequence. In the context of E-cadherin regulation in head and neck cancers, 2 major mechanisms including de novo promoter hypermethylation and microRNA dysregulation are most extensively studied. Both of them control E-cadherin expression at transcription level and subsequently hinder the overall E-cadherin protein level in the head and neck cancer cells. Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2. | - |
dc.language | eng | en_US |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html | - |
dc.relation.ispartof | Biomed Research International | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Interactions between E-cadherin and microRNA deregulation in head and neck cancers: The potential interplay | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, TS: thiansze@graduate.hku.hk | en_US |
dc.identifier.email | Gao, W: weigao@graduate.hku.hk | en_US |
dc.identifier.email | Chan, JYW: jywchan1@hku.hk | en_US |
dc.identifier.authority | Chan, JYW=rp01314 | en_US |
dc.identifier.authority | Wong, TS=rp00478 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2014/126038 | - |
dc.identifier.pmid | 25161999 | - |
dc.identifier.pmcid | PMC4138976 | - |
dc.identifier.scopus | eid_2-s2.0-84929939903 | - |
dc.identifier.hkuros | 233202 | en_US |
dc.identifier.volume | 2014 | en_US |
dc.identifier.isi | WOS:000340368100001 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2314-6133 | - |