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Article: Impact of nodal ratio on survival in recurrent nasopharyngeal carcinoma

TitleImpact of nodal ratio on survival in recurrent nasopharyngeal carcinoma
Authors
Issue Date2015
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347
Citation
Head & Neck, 2015, v. 37 n. 1, p. 12-17 How to Cite?
AbstractBACKGROUND: The purpose of this study was to investigate if nodal ratio has a prognostic role in the survival of patients with recurrent nasopharyngeal carcinoma (NPC) in the neck. METHODS: Patients with recurrent NPC in the neck who were treated in Queen Mary Hospital from 2000 to 2011 were identified. Clinical data, pathological results, and survival outcome were analyzed. RESULTS: Only nodal ratio remained as a statistically significant predictor in multivariate analysis for nodal recurrence (p = .045) and nodal recurrence-free survival (p = .010). All other predictors lost significance when compared with each other and with nodal ratio. Nodal ratio was also a significant predictor for overall survival (OS) in univariate analysis (p = .001) but lost its significance in multivariate analysis. The cutoff points 10% and 15% effectively stratified the patients into 3 risk groups (p = .02). CONCLUSION: In patients with NPC with neck recurrence, nodal ratio (the ratio of positive nodes to the total number of nodes examined) is a strong predictor of further nodal recurrence and nodal recurrence-free survival. Nodal ratio also impacts the OS but loses its significance in multivariate analysis, including concurrent local recurrence. Stratification of patients into low, medium, and high-risk groups according to nodal ratio may have a potential role in guiding therapeutic decision-making. Therefore, further exploration in this area is warranted. (c) 2013 Wiley Periodicals, Inc. Head Neck, 2014.
Persistent Identifierhttp://hdl.handle.net/10722/200930
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233

 

DC FieldValueLanguage
dc.contributor.authorChan, RCLen_US
dc.contributor.authorChan, JYWen_US
dc.date.accessioned2014-08-21T07:07:37Z-
dc.date.available2014-08-21T07:07:37Z-
dc.date.issued2015en_US
dc.identifier.citationHead & Neck, 2015, v. 37 n. 1, p. 12-17en_US
dc.identifier.issn1043-3074en_US
dc.identifier.urihttp://hdl.handle.net/10722/200930-
dc.description.abstractBACKGROUND: The purpose of this study was to investigate if nodal ratio has a prognostic role in the survival of patients with recurrent nasopharyngeal carcinoma (NPC) in the neck. METHODS: Patients with recurrent NPC in the neck who were treated in Queen Mary Hospital from 2000 to 2011 were identified. Clinical data, pathological results, and survival outcome were analyzed. RESULTS: Only nodal ratio remained as a statistically significant predictor in multivariate analysis for nodal recurrence (p = .045) and nodal recurrence-free survival (p = .010). All other predictors lost significance when compared with each other and with nodal ratio. Nodal ratio was also a significant predictor for overall survival (OS) in univariate analysis (p = .001) but lost its significance in multivariate analysis. The cutoff points 10% and 15% effectively stratified the patients into 3 risk groups (p = .02). CONCLUSION: In patients with NPC with neck recurrence, nodal ratio (the ratio of positive nodes to the total number of nodes examined) is a strong predictor of further nodal recurrence and nodal recurrence-free survival. Nodal ratio also impacts the OS but loses its significance in multivariate analysis, including concurrent local recurrence. Stratification of patients into low, medium, and high-risk groups according to nodal ratio may have a potential role in guiding therapeutic decision-making. Therefore, further exploration in this area is warranted. (c) 2013 Wiley Periodicals, Inc. Head Neck, 2014.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347en_US
dc.relation.ispartofHead & Necken_US
dc.rightsHead & Neck. Copyright © John Wiley & Sons, Inc.en_US
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)en_US
dc.titleImpact of nodal ratio on survival in recurrent nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.authorityChan, JYW=rp01314en_US
dc.identifier.doi10.1002/hed.23544en_US
dc.identifier.pmid24307492en_US
dc.identifier.hkuros231968en_US
dc.publisher.placeUnited Statesen_US

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